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EC number: 205-410-5 | CAS number: 140-29-4
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2a: Guideline study without detailed documentation
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- other: Peer-reviewed database
- Title:
- Biodegradation and bioconcentration of existing chemical substances under the chemical substances control law
- Author:
- MITI
- Year:
- 1 981
- Bibliographic source:
- http://www.safe.nite.go.jp/english/sougou/view/ComprehensiveInfoDisplay_en.faces, CAS n° 140-29-4
- Reference Type:
- other: Peer-reviewed database
- Title:
- Data bank of environmental properties of chemicals
- Author:
- Kemikaali
- Year:
- 2 010
- Bibliographic source:
- http://wwwp.ymparisto.fi/scripts/Kemrek/Kemrek.asp, CAS n° 140-29-4, Finnish Environment Insitute
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- yes
- Remarks:
- 2 weeks instead of 28 days
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenylacetonitrile
- EC Number:
- 205-410-5
- EC Name:
- Phenylacetonitrile
- Cas Number:
- 140-29-4
- Molecular formula:
- C8H7N
- IUPAC Name:
- 2-phenylacetonitrile
- Details on test material:
- No data
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data
Study design
- Oxygen conditions:
- not specified
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Concentration of sludge: 30 ppm
No further data - Duration of test (contact time):
- 2 wk
Initial test substance concentration
- Initial conc.:
- 100 other: ppm
Parameter followed for biodegradation estimationopen allclose all
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- TOC removal
- Details on study design:
- No data
Results and discussion
- Preliminary study:
- No data
- Test performance:
- No data
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 77
- Remarks on result:
- other: Indirect analysis
- Parameter:
- % degradation (TOC removal)
- Value:
- 96
- Remarks on result:
- other: Direct analysis
- Parameter:
- % degradation (O2 consumption)
- Value:
- 100
- Remarks on result:
- other: value determined by converting the amount of the product phenylacetic acid to the amount of phenylacetonitrile
- Details on results:
- No further data
BOD5 / COD results
- Results with reference substance:
- No data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the test conditions, according to indirect analysis 77% (BOD) and according to direct analysis 96% (TOC) and 100% (value determined by converting the amount of the product phenylacetic acid to the amount of phenylacetonitrile) of phenylacetonitrile was degradated after 2 weeks in a OECD guidline 301C test. Thus the substance should be considered as readily biodegradable according to the EC regulation n°1272/2008 and the former 67/548/EC regulation.
- Executive summary:
The authors tested the biodegradability of phenylacetonitrile (CAS n° 140-29-4) according to the OECD guideline 301C. They tested 100 ppm of the substance in a 30 ppm concentration of activated sludge using standard equipment. After two weeks 77% of the test substance was biodegradated according to indirect analysis (BOD) and according to direct analysis 96% (TOC) and 100% (value determined by converting the amount of the product phenylacetic acid to the amount of phenylacetonitrile). Thus phenylacetonitrile should be considered as readily biodegradable.
No data was available on the GLP procedure during this test. Few details are available, as a result the validity criteria could not be checked. However considering that the authors followed the OECD guideline 301C and reported the main information, the study should be considered as reliable with restrictions ( Guideline study without detailed documentation).
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