Phenylacetonitrile

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

other information

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: 2.g: Collection of data. Database

Data source

Reference

Reference Type:

other: Databank

Title:

Ecotox database

Author:

US EPA

Year:

2010

Bibliographic source:

http://cfpub.epa.gov/ecotox/quick_query.htm, CAS n° 140-29-4

Materials and methods

Principles of method if other than guideline:

No data

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Phenylacetonitrile

EC Number:

205-410-5

EC Name:

Phenylacetonitrile

Cas Number:

140-29-4

Molecular formula:

C8H7N

IUPAC Name:

2-phenylacetonitrile

Details on test material:

No data

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Details on test solutions:

PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (solvent):ethanol or 2-propane
- Concentration of vehicle:5 ppt
No more data

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Details on test organisms:

TEST ORGANISM
- Common name:rainbow trout
- Age at study initiation: fingerling
- Length at study initiation: <= 4 in

Study design

Water media type:

freshwater

Total exposure duration:

24 h

Test conditions

Test temperature:

55 F

pH:

7.5 to 8.2

Dissolved oxygen:

8.6 to 13.7 ppm

Nominal and measured concentrations:

5 mg/L

Results and discussion

Effect concentrations

Duration:

24 h

Dose descriptor:

LC0

Effect conc.:

>= 5 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

The toxicity of phenylacetonitrile to Oncorhynchus mykiss was tested. Under the test conditions, the LC0(24h) is equal to or higher than 5 mg/L.
At this level of information, the test substance cannot be classified according to the CLP regulation (EC) n° 1272/2008 as the total exposure duration was less than the required 96h.

Executive summary:

The databank reports the acute toxicity of phenylacetonitrile (CAS n° 140-29-4) on Oncorhynchus mykiss (Rainbow trout). Fingerlings with a maximum size of 4 inches were exposed to 5 mg/L of test substance dissolved in 5 ppt of ethanol or 2 -propanone during 24h in fresh water with a temperature of 55 F, a pH ranging from 7.5 to 8.2 and dissolved oxygen content ranging from 8.6 to 13.7 ppm. No effects were noted, thus the LC0(24h) is equal to or higher than 5 mg/L. At this level of information, the test substance cannot be classified according to the CLP regulation (EC) n° 1272/2008 as the total exposure duration was less than the required 96h.