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EC number: 224-536-1 | CAS number: 4402-30-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
1. Physical-chemical properties
1,1’-(methylimino)-dipropane-2-ol (MW 147.2 g/mol) is at RT a liquid with a measured boiling point of 225°C at 1013 hPa, a measured vapour pressure of 0.015 hPa at 20 °C, and a dissociation constant (pKa) of 7.86 at 25 °C. The octanol-water partition coefficient (log Pow) is -0.015 at 23 °C, and it is miscible with water in any ratio.
2. Data from acute and repeated dose toxicity studies
Acute toxicity data indicate low toxicity: in rats the oral LD50 was 2150 mg/kg bw (BASF AG, 1987). At this dose and above various clinical signs (dyspnea, apathy, staggering, piloerection, salivation, poor general state), general congestion and severe redness of forestomach, glandular stomach and small intestines were noted. At the highest dose group pink colouration of the urine (5000 mg/kg bw) was also detected. No reliable acute inhalation toxicity data are available for 1,1’-(methylimino)-dipropane-2-ol. However, due to its low vapour pressure, exposure to 1,1’-(methylimino)-dipropane-2-ol vapour is very unlikely. There is no repeated dose toxicity study with 1,1’-(methylimino)-dipropane-2-ol available. Nevertheless, a subacute as well as a subchronic study via the dermal (OECD TG 410) and oral route of exposure (performed according to FDA guidelines) were carried out with tris-(2-hydroxypropyl)-amine (CAS 122-20-3) and were used for cross reading.
In the oral repeated dose study, beagle dogs were administered 0, 500, 2000 or 7500 ppm tris-(2-hydroxypropyl)-amine in their diet for 102-104 days (Dupont, 1987). Ophthalmology, hematology, serum chemistry, urinalysis, blood methaemoglobin, macroscopic and microscopic examinations, and organ weight evaluations showed no treatment-related effects, resulting in a NOAEL of 272-288 mg/kg bw/day (the highest dose tested). In a dermal repeated dose study, rats were exposed to 0, 300, 1000 or 3000 mg/kg bw, 5 days/week for 28 days. Besides irritative effects at the site of application at the higher doses, no systemic toxicity was observed. A NOAEL for systemic effects of 3000 mg/kg bw/day was established (Dow, 1994).
3. Absorption, distribution, metabolism, excretion (ADME)
Concerning ADME, no studies are available with1,1’-(methylimino)-dipropane-2-ol. However, there are data on metabolism and excretion of 2,4-dichlorophenoxyacetate, 1,1’,1’’-nitrilotripropan-2-ol salt (2,4-D-TIPA), which were assessed in an OECD guideline 417 oral study in male Fischer 344 rats. A single oral dose, equivalent to 11.2 mg14C-TIPA/kg bw, was administered, followed by blood sampling at intervals up to 72 hours post-dose. Radioactivity peaked in the plasma at 0.25 hrs post-dosing and declined triexponentially. The kidney was the major route of excretion with about 80% of the dose excreted in 24 hours and 81 to 85% of the dose excreted in 72 hours, primarily unmetabolised. The feces and expired air accounted for only 4% to 7% and 3% to 5%, respectively. After 72 hours, 94% to 96% was recovered with only less than 1% remaining in the tissues or carcass (Dow, 1992). Since 2,4-D-TIPA is rapidly absorbed and eliminated in the rat, bioaccumulation is considered unlikely, which counts also for1,1’-(methylimino)-dipropane-2-ol.
Since no data regarding absorption, distribution, metabolism, excretion of 1,1’-(methylimino)-dipropane-2-ol are available, a complete bioavailability (100%) is assumed for the oral and dermal routes of exposure, which will result in a most conservative risk assessment.
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