Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reliability assigned to handbook data

Data source

Reference
Reference Type:
review article or handbook
Title:
No information
Year:
2006
Bibliographic source:
Merck index

Materials and methods

Principles of method if other than guideline:
See Merck index
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
O-acetylsalicylic acid
EC Number:
200-064-1
EC Name:
O-acetylsalicylic acid
Cas Number:
50-78-2
Molecular formula:
C9H8O4
IUPAC Name:
2-acetoxybenzoic acid
Test material form:
solid: crystalline

Results and discussion

Dissociating properties:
yes
Dissociation constant
No.:
#1
pKa:
3.49
Temp.:
25 °C

Applicant's summary and conclusion

Conclusions:
The substance pKa is 3.49 at 25 °C.