2,5-xylidine

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Authoritative database

Justification for type of information:

Data is from authoritative database.

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Principles of method if other than guideline:

Short-term toxicity of the test chemical was determined according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) on daphnia sp.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia sp.

Details on test organisms:

- Common name: Water flea

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Reference substance (positive control):

no

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

18 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

no

Conclusions:

Short-term toxicity to aquatic invertebrates was determined on the basis of mobility of daphnia for 48 hours. After the exposure of test chemical, the EC50 was determined to be at 18mg/l.

Executive summary:

A 48 hours study was conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) to determine the toxicity of the test material on daphnia in a static system. After 48 hours of exposure, EC50 was determined at 18 mg/l. Hence on the basis of above data, test chemical was classified under aquatic chronic 3

Description of key information

Study was conducted to determine the effect of test chemical on the immobility rate of daphnia. A 48 hours study was conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) to determine the toxicity of the test material on daphnia in a static system. After 48 hours of exposure, EC50 was determined at 18 mg/l. Hence on the basis of above data, test chemical was classified under aquatic chronic 3.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

18 mg/L

Additional information

Based on the experimental data, toxicity of test chemical was determined on the basis of immobility rate of aquatic invertebrates. The studies are summarized as below:

First study was conducted to determine the effect of test chemical on the immobility rate of daphnia. A 48 hours study was conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) to determine the toxicity of the test material on daphnia in a static system. After 48 hours of exposure, EC50 was determined at 18 mg/l. Hence on the basis of above data, test chemical was classified under aquatic chronic 3.

Second study was performed from secondary source to support the first experimental study for determining the toxicity of test chemical.

Test was performed to determine the toxicity of the test chemical on aquatic invertebrates (crustaceans). The value of LC50 was determined to be 62 mg/l, based on which the test chemical was considered to be toxic and can be classified under aquatic chronic 3.

Thus, based on the above experimental data, it can be concluded that the chemical is toxic and can be considered to be classified under aquatic chronic 3.