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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
review article or handbook
Title:
Acute oral toxiciy study of test chemical in rats
Author:
K.C. Back et. al.
Year:
1972
Bibliographic source:
National Technical Information Service.
Reference Type:
review article or handbook
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of test chemical on rats
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2,5-xylidine
EC Number:
202-451-0
EC Name:
2,5-xylidine
Cas Number:
95-78-3
Molecular formula:
C8H11N
IUPAC Name:
2,5-dimethylaniline
Test material form:
liquid
Details on test material:
- Name of test material: 2, 5-xylidine
- Molecular formula: C8H11N
- Molecular weight: 121.18
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
Not specified
Doses:
937mg/kg bw - 2135 mg/kg bw
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
Not specified
Statistics:
Not specified

Results and discussion

Preliminary study:
Not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 297 mg/kg bw
Based on:
test mat.
95% CL:
>= 937 - <= 2 135
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality observed
Clinical signs:
other: Not specified
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Acute oral toxicity value of test chemical to rats was determined to be LD50:1297 mg/kg with 95% confidence limits (937-2135).
Executive summary:

In acute oral toxicity study, rats were treated with test chemical at a concentration of 937 - 2135 mg/kg bw orally. 50% mortality was observed at 1297 mg/kg bw in treated rat. Therefore, LD50 was considered to be 1297 mg/kg bw with 95% confidence limits (937 -2135) when rats were treated with test chemical orally and the test chemical can be classified as acute oral toxic category 4 as per CLP regulation.