Registration Dossier
Registration Dossier
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EC number: 255-911-8 | CAS number: 42613-21-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines of the Department of Transportation (D. O. T.), Code of Federal Regulations, Title 49, Part 173
- Principles of method if other than guideline:
- Following a 7-day acclimation period, a series of range finding doses (2510 - 10000 mg/kg) were given by gavage to rats fasted overnight. Animals were observed 48 h for mortality. Based on the range finding results, five male and five female rats were gavaged in a similar manner. Body weights were recorded at dosing and at 48 hours for the survivors. Clinical signs were noted directly after dosing and at 4, 24 and 48 hours. Animals found dead or terminated at 48 hours were subjected to a macroscopic examination of the viscera. The LD50 was calculated according to the method of Litchfield and Wilcoxon, 1949.
- GLP compliance:
- no
- Test type:
- other: see below
- Limit test:
- no
Test material
- Reference substance name:
- 112926-00-8
- EC Number:
- 601-214-2
- Cas Number:
- 112926-00-8
- IUPAC Name:
- 112926-00-8
- Details on test material:
- - Name of test material (as cited in study report): Syloid 244
- Physical state: fine white powder
- Lot/batch No.: Can#21a
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 2510, 3980, 10000 and 31600 mg/kg
- No. of animals per sex per dose:
- one animal each for the doses 2510, 3980 and 10000 mg/kg and five animals each for the dose 31600 mg/kg
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 31 600 mg/kg bw
- Remarks on result:
- other: for 48 hours
Any other information on results incl. tables
Animals at the highest dose level (> 31600 µg/kg bw) were normal in appearance and behavior after dosing. Macroscopic changes were not observed in the viscera.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
