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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Reliability as taken from OECD SIDS "Synthetic amorphous silica and silicates", 2004.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
112945-52-5
EC Number:
601-216-3
Cas Number:
112945-52-5
IUPAC Name:
112945-52-5
Details on test material:
- Name of test material (as cited in study report): CAB-O-SIL M5
- Analytical purity: ca. 100%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
2.08 mg/L
No. of animals per sex per dose:
10
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 2.08 mg/L air (analytical)
Exp. duration:
4 h

Any other information on results incl. tables

Particle size distribution was measured using a Delron Cascade impactor (MMAD = 0.76 µm ± 3.11). Approx. 84% of the particles had a diameter of =3 µm, approx. 98% =10 µm.No animals died. Nasal discharge during exposure, crusty eyes, crusty nose and alopecia at days post-exposure. No macroscopic organ lesions, but in one animal discoloration of the lung.

Applicant's summary and conclusion