1,1-dimethoxytrimethylamine

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study with acceptable restrictions.

Data source

Reference

Reference Type:

publication

Title:

Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan

Author:

Chemicals Inspection & Testing Institute Japan, published by Japan

Year:

1992

Bibliographic source:

Japan Chemical Industry Ecology-Toxicology & Information Center (JETOC)

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

N,N-dimethylformamide

EC Number:

200-679-5

EC Name:

N,N-dimethylformamide

Cas Number:

68-12-2

IUPAC Name:

N,N-dimethylformamide

Details on test material:

- Name of test material (as cited in study report): Dimethylformamide
- Analytical purity: no data

Radiolabelling:

no

Sampling and analysis

Details on sampling:

Test fish sampling and analyses were conducted every 2 weeks, and control fish analysis before the initiation and the termination of exposure.

Test solutions

Vehicle:

no

Details on preparation of test solutions, spiked fish food or sediment:

Dilution water used for the test originated from underground water pumped up from the ground of Kurume Research Laboratories.
Water quality and conditions were monitored continuously to meet the ministerial ordinance of the Ministry of Health and Welfare (1978) and the water quality criteria for fisheries (1983).

Test organisms

Test organisms (species):

Cyprinus carpio

Details on test organisms:

Weight, length and lipid content of the test fish at the initiation of exposure:
weight: about 30 g length: about 10 cm lipid content: 2-6 %

Study design

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

56 d

Total depuration duration:

28 d

Test conditions

Test temperature:

The temperature was 25 °C +/- 2 °C

Dissolved oxygen:

the concentration of dissolved oxygen was 6 - 8 mg/l.

Nominal and measured concentrations:

2 µg/L
20 µg/L

Reference substance (positive control):

no

Results and discussion

Lipid content

Lipid content:

2 - 6 %

Time point:

start of exposure

Bioaccumulation factor

Type:

BCF

Value:

0.3 - 1.2 L/kg

Basis:

whole body w.w.

Remarks on result:

other: Conc.in environment / dose:20 µg/L

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The revealed BCF range of 03 -1.2 indicate a very low bioaccumulation potential.

Executive summary:

An aquatic bioaccumulation test according to OECD guideline 305C was performed with two test substance concentration levels.

The revealed BCF range of 03 -1.2 L/kg indicate a very low bioaccumulation potential.