Registration Dossier
Registration Dossier
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EC number: 225-063-3 | CAS number: 4637-24-5
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without GLP and analytics but acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-Cut Chronic Toxicity Estimates Using Daphnia magna.
- Author:
- Adams WJ, Heidolph BB (1985):
- Year:
- 1 985
- Bibliographic source:
- ASTM Spec. Tech. Publ. 854, 87-103.
Materials and methods
- Principles of method if other than guideline:
- Semi-Static toxicity test
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS
TS-Freetext:
N,N-Dimethylformamide, technical grade.
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Water media type:
- freshwater
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 3 721 mg/L
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 500 mg/L
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 3 000 mg/L
- Duration:
- 21 d
- Dose descriptor:
- other: GM-MATC
- Effect conc.:
- 2 121 mg/L
Any other information on results incl. tables
RS-Freetext:
NOECs/LOECs (mg/L) depending on measured endpoint after 21 days:
NOEC (reproduction): 1500 mg/L
LOEC (reproduction): 3000 mg/L
NOEC (mortality): 3000 mg/L
LOEC (mortality): 6000 mg/L
NOEC (growth): 3000 mg/L
LOEC (growth): 6000 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
NOECs/LOECs (mg/L) depending on measured endpoint after 21 days:
NOEC (reproduction): 1500 mg/L
LOEC (reproduction): 3000 mg/L
NOEC (mortality): 3000 mg/L
LOEC (mortality): 6000 mg/L
NOEC (growth): 3000 mg/L
LOEC (growth): 6000 mg/L
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