Registration Dossier
Registration Dossier
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EC number: 202-090-9 | CAS number: 91-68-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- ASSESSMENT OF THE ACUTE TOXICITY AND POTENTIAL IRRITANCY OF HAIR DYE CONSTITUENTS
- Author:
- G. K. LLOYD, M. P. LIGGETT, S. R. KYNOCH and R. E. DAVIES
- Year:
- 1 977
- Bibliographic source:
- Fd Cosmet. Toxicol. Vol. 15, pp. 607-610 1977.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.41, Method of testing primary irritant substances)
- Principles of method if other than guideline:
- Irritation potential of resorcinol was assessed in New Zealand White rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Resorcinol
- Cas Number:
- Resorcinol
- Molecular formula:
- C6H6O2
- IUPAC Name:
- Resorcinol
- Reference substance name:
- 1,3-Benzenediol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- 1,3-Benzenediol
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- 1,3 benzenediol
- Details on test material:
- - Name of test material (as cited in study report):resorcinol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: intact or abraded
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 2.5%
- Observation period:
- 72 hrs
- Number of animals:
- three animals.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hrs
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: Not irritating
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance resorcinol was found to be not irritating to rabbit when applied at 2.5% concentration to intact or abraded skin
- Executive summary:
The substance resorcinol was found to be not irritating to rabbit when applied at 2.5% concentration to intact or abraded skin
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