3-diethylaminophenol

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

other: Predicted data

Title:

[R]: 44 mg/kg bw/day; Estimation for NOAEL, NOAEL (fertility), NOAEL (general toxicity), NOAEL (offspring), NOAEL parental toxicity, NOAEL reproductive effects, NOEL for CAS 91-68-9

Author:

Sustainability Support Service (Europe) AB

Year:

2014

Bibliographic source:

SSS QSAR team

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 3.1

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3 diethylamino phenol

IUPAC Name:

3 diethylamino phenol

Constituent 2

Reference substance name:

3-diethylaminophenol

EC Number:

202-090-9

EC Name:

3-diethylaminophenol

Cas Number:

91-68-9

Molecular formula:

C10H15NO

IUPAC Name:

3-(diethylamino)phenol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

90 days

Frequency of treatment:

daily

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:

NOAEL

Effect level:

44 mg/kg bw/day

Based on:

test mat.

Basis for effect level:

other: developmental toxicity

Results (fetuses)

Effect levels (fetuses)

Remarks on result:

not measured/tested

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

The NOAEL for 3-diethylaminophenol is estimated to be 132 mg/kg bw/day for rat in 10 days , this subacute value when converted to subchronic value using same species is equivalent to 44 mg/kg bw/day

Executive summary:

The NOAEL for 3-diethylaminophenol is estimated to be132mg/kg bw/dayfor rat in10 days, this subacute value when converted to subchronic value using same species is equivalent to 44mg/kg bw/day using the toolbox version 3.2. The data is estimated to be based on the data summarized below

CAS no.	End point	Value	Species	Doses	Duration	Effects	Remarks
95-48-7	NOAEL	101mg/kg bw/day	Rat	0, 30, 175, 450mg/kg/day	37 weeks	There were no treatment related developmental effects observed
106-44-5	NOAEL	114 mg/kg bw/day	Rat	0, 30, 175, 450mg/kg/day	Day 6-15 of gestation	No developmental effects observed
108-39-4	NOAEL	155mg/kg bw/day	Rat	0, 30, 175, 450mg/kg/day	Day 6-15 of gestation	No fetotoxicityor malformations observed
108-95-2	NOAEL	90.0 mg/kg bw/day	Rats	0, 60, 120, 360 mg/kg bw/day	Day 6-15 of gestation	no effects observed on fetal development
89-83-8	NOEL	200 mg/kg bw/day	Rat	0 , 8, 40, 200mg/kg/day actual ingested	males: 43 days females: from 14 days before mating to day 3 of lactation	No developmental effects observed
123-31-9	NOEL	75.0 mg/kg bw/day	Rabbit	0, 25, 75 or 150 mg/kg bwnominal conc.	gestation days 6 - 18	no developmental alteration observed
108-46-3	NOAEL	277mg/kg bw/day	Rat	0,125, 250, 500 mg/kg bw	6-15 days of gestation	No embryotoxic, fetotoxic or teratogenic effects observed

 

All the values when equalized to 90 days duration by using conversion factor of 3, the values are summarized as follows

CAS no.	End point	Value	Species	Duration
95-48-7	NOAEL	202 mg/kg bw/day	Rat	90 days
106-44-5	NOAEL	38 mg/kg bw /day	Rat	90 days
108-39-4	NOAEL	51.66 mg/kg bw/day	Rat	90 days
108-95-2	NOEL	30 mg/kg bw /day actual ingested	Rat	90 days
89-83-8	NOAEL	66.66 mg/kg bw /day nominal conc	Rat	90 days
123-31-9	NOEL	15 mg/kg bw /day nominal conc	Rat	90 days
108-46-3	NOAEL	92.333mg/kg bw /day	Rat	90 days

 

Thus the calculated NOEL of analogues for 90 days for the species rat is within the range of 15-202 mg/kg bw /day. Thus the predicted NOEL value is (calculated to be)70.807mg/kg bw/d with 90 days for rat (harmonized using assessment factors) falls within the domain using Log Kow as the descriptor and justified to be used as NOEL for further DNEL calculation for the purpose of risk assessment. Also it does not impact the classification of the substance thus the predicted value considered to be acceptable.

Justified to be used as NOEL for the purpose of weight of evidence