Lead sulphate

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented publication which meets basic scientific principles

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2002

Materials and methods

Study type:

study with volunteers

Endpoint addressed:

dermal absorption

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The objective of this study was to determine percutaneous absorption of lead compounds, including lead sulfate. The lead content on the skin surface of 10 lead-battery workers was measured by the method of skin stripping.

GLP compliance:

not specified

Method

Subjects:

- Number of subjects exposed: 10
- Sex: males
- Other: Lead battery workers

Route of exposure:

dermal

Reason of exposure:

unintentional, occupational

Exposure assessment:

not specified

Results and discussion

Clinical signs:

The total amount of lead obtained in the 10 strips of the dorsal hand ranged from 20.74 to 86.53 µg, and of the low back ranged from 8.94 to 28.32 µg. The total amount of lead dorsal hand was linearly correlated with the amount in blood (n=10, r²=0.6586, p<0.05, linear regression, figure 2b). There was a decreasing amount of lead content in the exposed skin going from the outer to the inner layers.

Applicant's summary and conclusion

Conclusions:

In the conditions of the study, we cannot conclude about the absorption of lead sulfate in human.