Registration Dossier
Registration Dossier
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EC number: 215-246-6 | CAS number: 1314-87-0
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Cytotoxicity and mutagenicity of "Al-Kohl", an eye cosmetic commonly used in Jordan
- Author:
- A.S. Alkofahi, A.A. Abdelaziz and I.I. Mahmoud
- Year:
- 1 989
- Bibliographic source:
- Journal of Clinical Pharmacy and Therapeutics
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 72-3 (Estuarine/Marine Fish, Mollusk, or Shrimp Acute Toxicity Test)
- Deviations:
- yes
- Principles of method if other than guideline:
- Meyer & Al. (1982) Brine shrimp. A convenient general bioassay for active plant constituents.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): Al Kohl
- Other: contains more or less of lead sulfide
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other aquatic crustacea: Brine Shrimp
Study design
- Test type:
- not specified
- Water media type:
- saltwater
- Total exposure duration:
- 24 h
Results and discussion
Any other information on results incl. tables
24% of the samples tested have strong cytotoxic effect, 16% are mildly cytotoxic and 60% are non-cytotoxic
The cytotoxicity observed might be due to the materials added during the preparation of Al-Kohl. These materials are widely different in their nature and are used in different quantities. This may explain why some samples are cytotoxic while others samples are not.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In the conditions of the studies, lead sulfide cannot be considered as toxic due to the substance tests.
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