Registration Dossier
Registration Dossier
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EC number: 215-246-6 | CAS number: 1314-87-0
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Lead sulphide
- EC Number:
- 215-246-6
- EC Name:
- Lead sulphide
- Cas Number:
- 1314-87-0
- Molecular formula:
- PbS
- Details on test material:
- - Name of test material (as cited in study report): lead sulfide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley and Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intratracheal
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- no
- Frequency of treatment:
- Single dust application, in several doses of 15 mg
- Post exposure period:
- From 24 h to 6 months
Doses / concentrations
- Remarks:
- Doses / Concentrations:
15 mg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 20 male Sprague-Dawley/application
60 female Wistar/application - Control animals:
- no
Examinations
- Examinations:
- Lungs under light microscopic investigation, transmission electron microscopy (TEM) and scanning electron microscopy (SEM)
Results and discussion
- Details on results:
- Necroses of the alveolar septae and accumulation of dust-laden macrophages were observed
No transcellular penetration of dust particles into the pulmonary interstitium or immigration of dust-laden macrophages into the pulmonary stroma was observed
Applicant's summary and conclusion
- Conclusions:
- The postulate that dust-laden alveolar macrophages can pass through the intercellular junctions of intact pneumocytes into the pulmonary interstitium can neither be excluded nor confirmed on the basis of the present investigation. However, the often very close attachment of the pseudopodia of the alveolar macrophages to the type I pneumocytes suggests such a possibility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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