Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Study period:
Start of experiment: 15 March 1999; Experiment end date - 17 March 1999; Study completion date - 28 April 1999.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
OECD 117, Directive 92/69/EC, A.8 Estimation from solubility in n-octanol and water
GLP compliance:
yes (incl. QA statement)
Type of method:
other: estimated from the solubility of test substance in water and n-octanol
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
The test article had the following physico-chemical properties:
Name: 40574/B
Batch no: WP 23/PP
Expiry date: 08 February 2006
Storage: At room temperature about 20 °C.
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
ca. -5
Temp.:
20 °C
Remarks on result:
other: pH not determinated

Based on the results of the pretest, neither the flask method nor the HPLC-method were applicable for the determination of the Log Po/w. Therefore, the value was estimated from the solubility of test substance in water and n-octanol.

Conclusions:
The partition coefficient, log Pow, of FAT 40'574/B was estimated to be - 5
Executive summary:

In the present study the n-octanol/water partition coefficient of FAT 40574/B was estimated using a calculation method according to EEC Directive 92/69. In the preliminary test, a very good solubility in water and a very poor solubility in n-octanol was found indicating a partition coefficient far below -2. Hence, a main test according to OECD Guidelines 107/117 (either HPLC or flask shaking method) could not be applied. Therefore, the partition coefficient of FAT 40574/B was estimated using the solubility data in n-octanol as obtained in the preliminary test. Based on the findings of this study, the partition coefficient, log Pow, of FAT 40574/B was estimated to be - 5.

Description of key information

The calculated partition coefficient of the test substance between n-octanol and aqueous phase is: log Pow = -5. A log Kow value of -1 is used in the assessment (minimum value for EUSES).

Key value for chemical safety assessment

Log Kow (Log Pow):
-5
at the temperature of:
20 °C

Additional information

In the present study the n-octanol/water partition coefficient of FAT 40574/B was estimated using a calculation method according to EEC Directive 92/69. In the preliminary test, a very good solubility in water and a very poor solubility in n-octanol was found indicating a partition coefficient far below -2. Hence, a main test according to OECD Guidelines 107/117 (either HPLC or flask shaking method) could not be applied. Therefore, the partition coefficient of FAT 40574/B was estimated using the solubility data in n-octanol as obtained in the preliminary test. Based on the findings of this study, the partition coefficient, log Pow, of FAT 40574/B was estimated to be - 5.