Registration Dossier
Registration Dossier
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EC number: 251-178-3 | CAS number: 32724-62-2
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Read-Across on Reinblau RLW, Key, Rel 2; Test Method Relating to New Chemical Substances (Kanpogyo No.5, Yakuhatsu No.615, 49 Kikyoku No.392, 1974, amended 1998)/similar to OECD 305; Mitsubishi (2011): BCF=2-5
On the basis of the BCF obtained and category approach, it is concluded that the bioaccumulation potential of the Reinblau BLW (CAS n°32724-62-2) in fish is low under the test condition.
Key value for chemical safety assessment
- BCF (aquatic species):
- 5 dimensionless
Additional information
Additional information:
The concentration of the test substance in fish ranged from 0.37 to 1.08 µg/g (w/w) and the bioconcentration (BCF) was 2 to 5 (Mitsubishi, 2011). On the basis of the BCF obtained, it is concluded that the bioaccumulation potential of the test substance in fish is low under the test condition.
As the test substance has a very low water solubility HCO-30 was used as solubilizer in the test system. If possible no solubilizer should be applied to the test system. But as the results for the BCF are very small and the usage of a solubilizer is increasing the concentration of the test substance in the test system, the present result can be used as a worst case displaying a very low bioaccumulation potential for the substance under environmentally relevant conditions.
Category approach:
A category approach has been defined (see attached justification document in section 13). The category consists of substances all having the diamino-anthraquinone structure as a common moiety which is linked to phenyl groups via the amino groups. Differences within the category are described by various alkyl groups bound to the phenyl groups. All substances included in the category approach are poorly water soluble with high adsorption coefficient (log Koc>6), high partition coefficient (logKow>8) and not readily biodegradable.
Data available on other members of the category confirmed the low bioaccumulation of the substances:
| Reinblau RLW (CAS n°41611-76-1) | similar to OECD 305 | BCF=2-5 L/kg |
| Reinblau RLW (CAS n°41611-76-1) | QSAR (EPI) Suite V4.11 - BCFBAF v3.01 | BCF= 569 L/kg |
| Green 3 (CAS n°128-80-3) | QSAR (EPI) Suite V4.11 - BCFBAF v3.01 | BCF=893 L/kg |
| Violet 36 (CAS n° 82-16-6) | QSAR (EPI) Suite V4.11 - BCFBAF v3.01 | BCF=798 L/kg |
| Green 28 (CAS n° 4851-50-7) | QSAR (EPI) Suite V4.11 - BCFBAF v3.01 | BCF=53 L/kg |
| Blue 104 (CAS n°116-75-6) | QSAR (EPI) Suite V4.11 - BCFBAF v3.01 |
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