Registration Dossier
Registration Dossier
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EC number: 251-178-3 | CAS number: 32724-62-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- Justification Document for the Category of Six Anthraquinone Dyes
LANXESS Deutschland GmbH has registered five mono-constituent anthraquinone dyes of similar chemical structure using a category approach: Solvent Violet 36 (CAS No 82-16-6), Solvent Green 3 (CAS No 128-80-3), Reinblau RLW (CAS No 41611-76-1), Reinblau BLW (CAS No 32724-62-2) and Solvent Green 28 (CAS No 4851-50-7). Additional data were taken from another registered anthraquinone dye, Solvent Blue 104 (CAS No 116-75-6), leading to a category consisting of six members (see attached justification in the Category dossier).
Data source
Materials and methods
Test material
- Reference substance name:
- 1,4-bis[(2,6-diethyl-4-methylphenyl)amino]anthraquinone
- EC Number:
- 251-178-3
- EC Name:
- 1,4-bis[(2,6-diethyl-4-methylphenyl)amino]anthraquinone
- Cas Number:
- 32724-62-2
- Molecular formula:
- C36H38N2O2
- IUPAC Name:
- 1,4-bis[(2,6-diethyl-4-methylphenyl)amino]-9,10-dihydroanthracene-9,10-dione
Constituent 1
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: other:
Any other information on results incl. tables
Clinical Signs
A dose of 2000 mg/kg body weight was tolerated by males and females without toxicologically relevant clinical signs. Locally, a blue discoloration of the treatment area was observed.
The most plausible interpretation is a discoloration by the blue color of the test item (which is not considered a toxicologically relevant effect).
Body Weights
There were no toxicologically significant effects on body weight or body weight development in males and females.
Gross Pathology Findings
The necropsies performed at the end of the study revealed no particular findings.
Applicant's summary and conclusion
- Executive summary:
Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test item applied semioclclusively for 24 hours.
None of the animals died. A dose of 2000 mg/kg body weight was tolerated by males and females without toxicologically relevant clinical signs. There were no toxicologically significant effects on body weight or body weight development in males and females.
The necropsies performed at the end of the study revealed no particular findings.
LD50 > 2000 mg/kg bw (rat, male + female)
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