Registration Dossier
Registration Dossier
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EC number: 447-060-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
An acute oral toxicity and an acute dermal toxicity study were performed. The LD50 were >2000 mg/kg bw in both studies.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute oral and dermal toxicity were assessed in two valid GLP studies according to OECD TG 423 and 402, respectively. Acute inhalation toxicity was not assessed because the vapour pressure of the substance is very low (0.000325 Pa at 25°C) and exposure to aerosols, particles or droplets of an inhalable size is not anticipated with the uses of the substance.
In the oral toxicity test, rats received a single oral gavage dose of the test substance at a dose level of 2000 mg/kg. All animals were killed as scheduled and examined macroscopically at the end of the observation period (day 15). No signs of toxicity were observed and the acute lethal oral dose of DV6850 in rats was demonstrated to be greater than 2000 mg/kg bodyweight.
In the dermal toxicity test, rats received a single topical application of the test substance at a dose level of 2000 mg/kg bodyweight. All animals were killed and examined macroscopically at the end of the observation period (day 15). Dermal irritation, desquamation, spots and/or scabbing were observed in some animals and persisted until study termination in some of the affected animals. No or notably low bodyweight gains were observed for three females on Day 8 and/or Day 15. All other animals were considered to have achieved satisfactory bodyweight gains throughout the study. There were no deaths and no systemic response to treatment in any animal throughout the study. The acute lethal dermal dose of DV6850 in rats was demonstrated to be greater than 2000 mg/kg bodyweight.
Justification for classification or non-classification
As the acute lethal oral and dermal dose to rats of DV6850 was demonstrated to be greater than 2000 mg/kg bodyweight, the test item DV6850 does not have to be classified for acute toxicity according to according to the criteria of Directive 67/548/EEC (DSD) or Regulation (EC) No. 1272/2008 (CLP).
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