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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guidelinestudy under GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-α,α,α-trifluoro-o-toluidine
EC Number:
207-151-3
EC Name:
4-chloro-α,α,α-trifluoro-o-toluidine
Cas Number:
445-03-4
Molecular formula:
C7H5ClF3N
IUPAC Name:
4-chloro-2-(trifluoromethyl)aniline

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: oleum sesami
Doses:
Female: 1250, 1600, 1800, 2000, 2250 mg/kg
Male: 1600, 2000, 2250 mg/kg
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
1 900 mg/kg bw
Based on:
not specified
Sex:
male
Dose descriptor:
LD50
Effect level:
1 980 mg/kg bw
Based on:
not specified
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 940 mg/kg bw
Based on:
not specified

Applicant's summary and conclusion