Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 441-100-8 | CAS number: 351197-46-1
Endpoint summary
Administrative data
Description of key information
skin: Not irritating (Arcelin, 2002)
eye: Risk of serious damage to eyes (Arcelin, 2002)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin
The primary skin irritation potential of UAX-1179 was investigated by topical semi-occlusive application of 0.5 mL to the intact left flank of each of three young adult New Zealand White rabbits under GLP according to OECD TG 404 (Arcelin, 2002). The test item did not elicit any skin reactions at the application site of any animal at the 24-, 48- and 72-hour readings (all scores 0). Thus, UAX-1179 is considered to be “not irritating” to rabbit skin.
Eye
The primary eye irritation potential of UAX-1179 was investigated by instillation of 0.1 mL into the left eye of one young adult New Zealand White rabbit in a GLP-Guideline study (Arcelin, 2002). The eye reactions (mean values from 24 to 72 hours) consisted of grade 3.00 corneal opacity, grade 1.00 iris lesions, grade 2.00 redness of the conjunctivae and grade 2.00 chemosis of the conjunctivae.
The instillation of UAX-1179 into the eye of a single male rabbit resulted in moderate to severe ocular changes. The animal vocalized immediately after treatment and a marked opacity, affecting up to the whole area of the cornea was present at the 1-hour reading. The corneal opacity accompanied by reddening of the conjunctivae and sclera, swelling and discharge were evident throughout the 72 hour observation period. Blood was also present around the eye at the 1-hour reading and ruptured blood vessels were evident during the observation period. There was no indication of reversibility of the effects at the 72-hour reading and the animal displayed signs of distress and pain during the examination. Based on these results the animal was prematurely sacrified and no further animals were treated. Based upon the classification criteria of EEC Commission Directive 93/21/EEC of April 27, 1993, UAX-1179 is considered to be “R41- Risk of serious damage to eyes”.
Respiratory tract
There is no data for Irritation to respiratory tract by UAX-1179. Exposure of humans by inhalation is not likely because of the low vapour pressure of UAX-1179. The formation of aerosol can be excluded by uses (see 3.5).
Effects on eye irritation: highly irritating
Justification for classification or non-classification
DSD: Xi; R41, risk of serious eye damage
CLP: Eye damage cat 1; H318, Causes serious eye damage, with signal word: danger
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
