Registration Dossier
Registration Dossier
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EC number: 927-033-1 | CAS number: 1174918-88-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There are no skin sensitisation data available on hydrocarbons, C7-C8, cyclics. However, there are reliable data available for another category member. Thus, read-across was conducted based on a category-approach.
The skin sensitization potential of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics, was studied in a guinea pig maximization test (Magnusson/Kligman method) similar to OECD 406. Guinea pigs (10/sex in treated group and 5/sex in control group) were induced with 1% (w/v) of the test substance in corn oil as a 0.1 ml injection in the shaved shoulder region. Six to eight days later a topical induction of 50% (w/v) test material was applied under an occlusive dressing for 48 hrs. On Day 20-21 guinea pigs were challenged with 25% (w/v) test material applied to the shaved flank. Skin response was evaluated immediately after challenge, and 24 and 48 hours later. The test substance did not cause indication of skin sensitization in any guinea pig at any evaluation period after challenge (Shell Chemicals, 1977).
Migrated from Short description of key information:
Based on read-across from a structurally related substance within a category approach, hydrocarbons, C7-C8, cyclics are not considered to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data available.
Justification for classification or non-classification
Based on read-across from a structurally related substance within a category approach, the available data on the skin sensitisation potential of hydrocarbons C7-C8, cyclics are conclusive but not sufficient for classification.
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