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Physical & Chemical properties

Water solubility

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Administrative data

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01.08.1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Directive 92/69/EEC
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
130 mg/L
Conc. based on:
test mat.
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 5.8 - <= 6
Details on results:
The preliminary test determined the water solubility to be approximately 0.277 g/L.

Sample number

Time shaken at
30 °C (hours)

Time held at
20 °C (hours)

Concentration (g/L)

Solution pH

1

24

25

0.132

5.8

2

48

25

0.126

6.0

3

72

25

0.132

6.0

Mean concentration = 0.130 g/L = 130 mg/L

Range = 0.126 - 0.132 g/L

Conclusions:
The water solubility of the test item was determined to be 130 mg/L at 20 °C and pH 6.
Executive summary:

The water solubility was determined according to Directive 92/69/EEC method A.6 using the shake flask method with HPLC analysis.A preliminary test was undertaken to determine the approximate water solubility. Based on the preliminary result, aliquots of test material, were weighed into three separate flasks. After addition of glass double-distilled water to the flasks, they were shaken at approximately 30 °C and, after standing at 20 °C for a period of not less than 24 hours, the contents of the flasks were filtered and the concentrations determined by HPLC.The water solubility of the test substance was determined to be 130 mg/L at 20 °C and pH = 6.

Description of key information

The water solubility of the test item was determined to be 130 mg/L at 20 °C and pH 6 (reference 4.8-1).

Key value for chemical safety assessment

Water solubility:
130 mg/L
at the temperature of:
20 °C

Additional information

The water solubility was determined according to Directive 92/69/EEC method A.6 using the shake flask method with HPLC analysis. A preliminary test was undertaken to determine the approximate water solubility. Based on the preliminary result, aliquots of test material, were weighed into three separate flasks. After addition of glass double-distilled water to the flasks, they were shaken at approximately 30 °C and, after standing at 20 °C for a period of not less than 24 hours, the contents of the flasks were filtered and the concentrations determined by HPLC. The water solubility of the test substance was determined to be 130 mg/L at 20 °C and pH = 6.