Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 222-746-8 | CAS number: 3598-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Guidance on Safe Use
Administrative data
First-aid measures
In case of disorders consult a doctor.
After inhalation:
Provide fresh air. In case of disorders or if you feel unwell, seek medical advice.
After skin contact:
After contact with skin wash immediately with plenty of water and soap. In case of disorders, consult a physician.
After eye contact:
Immediately rinse eyes thoroughly with running water. Protect uninjured eye, remove contact lenses. In case of disorders, consult a physician.
After swallowing:
Rinse mouth with water. Do not induce vomiting. Call a physician immediately. Never give anything by mouth to an unconscious person.
Indication of any immediate medical attention and special treatment needed:
Treat symptomatically.
Fire-fighting measures
applicable: Water spray or fog, foam, dry chemical powder, CO2, sand.
not applicable: Water with full jet
Special hazards arising from the substance or mixture:
This material is assumed to be combustible. Formation of toxic gases (carbon oxides) is possible during heating or in case of fire. Avoid dispersion of dust/aerosols.
Advice for fire fighters:
As with all fires, evacuate personnel to a safe area. Fire fighters should use a self-contained breathing apparatus and full protective clothing.
Accidental release measures
Wear personal protection equipment. Avoid generation of dust/aerosols. Provide adequate ventilation. Do not breathe dust/aerosols.
Environmental precautions:
Do not allow to penetrate into soil, waterbodies or drains.
Methods and material for containment and cleaning up:
Pick up mechanically and arrange disposal without creating dust. Place spillage in suitable closed containers for disposal. Wash the contaminated area with plenty of water.
Reference to other sections:
See section 7 (handling and storage), section 8 (personal protection), section 13 (disposal) SDS
Handling and storage
Preventive measures:
As a general rule, when handling this material, avoid all contact and inhalation of dust/aerosols. Wash hands after handling. Provide adequate ventilation and local exhaust as needed. Use personal protective clothing. Avoid formation of dust and aerosols.
Information about fire- and explosion protection:
No special measures required.
Information for safe handling:
Ensure good ventilation/exhaustion.
Conditions for safe storage, including any incompatibilities:
Information about storage conditions:
Keep away from combustible materials and sources of heat and ignition. Check all containers are clearly labelled and free from leaks. Materials to avoid: strong oxidizing agents, strong acids
Requirements at store rooms and containers:
Store container tightly closed in a dry area. Store in a cool place. Avoid heat and sunlight.
Storage class: TRGS 510, VCI (Germany) 11 (combustible solids)
Specific end use(s)
Branch and sector- specific guidelines: none known
Further information:
The substance must be handled under strictly controlled conditions as laid out in Article 18 paragraph 4 REACH-regulation. DETAILED information on risk management measures recommended to the user in accordance with Art. 18 paragraph 4 and ECHA REACH Guidance on intermediates (2010), Annex 3 and Practical Guide 16 (2014) is attached to section 13 of the IUCLID dossier.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- not applicable
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Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- not applicable
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Marine transport (UN RTDG/IMDG)
- UN number:
- not applicable
Shipping information
- Proper shipping name and description:
- not applicable
- Chemical name:
- not applicable
- Labels:
- not applicable
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Air transport (UN RTDG/ICAO/IATA)
- UN number:
- not applicable
Shipping information
- Proper shipping name and description:
- not applicable
- Chemical name:
- not applicable
- Labels:
- not applicable
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Exposure controls / personal protection
Engineering controls such as exhaust ventilation are recommended.
Individual protection measures, such as personal protective equipment:
General measures: Avoid contact with skin and eyes. Take off immediately all contaminated clothing. When using do not eat, drink or smoke. After work wash hands.
Eye/face protection: Wear safety goggles.
Skin/body protection: Wear suitable protective clothing.
Hand protection: Protective gloves. Recommended materials: natural latex or rubber gloves.
Respiratory protection: In case of dust: particulates filter (type: depending on exposure)
Environmental exposure controls:
See chapter 6.2. SDS. No additional measures necessary.
Further information:
The substance must be handled under strictly controlled conditions as laid out in Article 18 paragraph 4 REACH-regulation. DETAILED information on risk management measures recommended to the user in accordance with Art. 18 paragraph 4 and ECHA REACH Guidance on intermediates (2010), Annex 3 and Practical Guide 16 (2014) is attached to section 13 of the IUCLID dossier.
Stability and reactivity
Hazardous polymerisation will not occur.
Conditions to avoid:
Avoid heating, sunlight, all sources of ignition.
Incompatible materials:
Strong oxidizing agents, strong acids
Hazardous decomposition products:
Carbon monoxide, carbon dioxide. In case of fire: see section 5.2 SDS.
Disposal considerations
Dispose of in compliance with federal, state and local regulations.
Waste key number: 0705 wastes from the manufacture, formulation, supply and use (MFSU) of pharmaceuticals
Uncleaned packaging:
Dispose of in compliance with federal, state and local regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.