Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 629-348-7 | CAS number: 23357-52-0
Endpoint summary
Administrative data
Description of key information
The median lethal dose of 1-Aminotetralin (read across, CAS 2217-40-5) after oral administration was found to be greater than 300 mg/kg and less than 500 mg/kg body weight in rats (OECD 423).
Key value for chemical safety assessment
Additional information
The study was performed to assess the acute toxicity following oral administration of 1-Aminotetralin (read across, CAS 2217-40-5) in Wistar rats. Single doses of 500 and 300 mg/kg body weight of test material preparations in olive oil Ph.Eur./DAB were given to three administration groups of three fasted female animals, each, (500 mg/kg in 3 females, 300 mg/kg in 6 females) by gavage in a sequential manner. Two animals of the 500 mg/kg administration group were found dead within 4 hours after application. No mortality occurred in the 300 mg/kg administration groups. During necropsy one animal that died in the 500 mg/kg administration group showed red erosion/ulcer in the glandular stomach. No macroscopic pathologic abnormalities were noted in the other animal that died (500 mg/kg: 1 female) and in the animals examined at the end of the observation period (500 mg/kg: 1 female; 300 mg/kg: 6 females). Under the conditions of this study the median lethal dose of 1-Aminotetralin after oral administration was found to be greater than 300 mg/kg and less than 500 mg/kg body weight in rats. [BASF, 2006]
Justification for classification or non-classification
Based on the available data for 1-Aminotetralin (read across, CAS 2217-40-5) (S)-1-Aminotetralin is subject to C&L:
according to Regulation 1272/2008/EC: acute oral tox. 4, H302 and
according to Directive 67/548/EEC: acute oral tox.: R22
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
