Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-173-9 | CAS number: 34730-59-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 2-[(2-aminoethyl)amino]ethanesulphonate
- EC Number:
- 252-173-9
- EC Name:
- Sodium 2-[(2-aminoethyl)amino]ethanesulphonate
- Cas Number:
- 34730-59-1
- Molecular formula:
- C4H12N2O3S.Na
- IUPAC Name:
- sodium 2-(2-aminoethylamino)ethanesulfonate
- Details on test material:
- - Composition of test material, percentage of components: approximately 50% active compound in water
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann, Borchen, Germany
- Age at study initiation: 7 - 10 weeks
- Weight at study initiation: mean males 197 g, mean females 175 g
- Fasting period before study: 16 - 4
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The content of 50% active ingredient in the test substance was taken into account for dosis calculation.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- other: LD50 cut-off
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: The treatment was tolerated without mortalites, clinical signs, effects on body weights and gross pathological findings.
- Mortality:
- no deaths
- Clinical signs:
- other: none
- Gross pathology:
- no findings
- Other findings:
- none
Any other information on results incl. tables
| Dose (mg/kg bw) | Toxicological results | Onset and duration of signs | Onset of mortality |
| (1st) 2000 | 0 / 3/ 3 | --- | --- |
| (2nd) 2000 | 0 / 3/ 3 | --- | --- |
Toxicological results:
number of dead animals / number of animals with signs of toxicity after treatment / number of animals treated
Applicant's summary and conclusion
- Executive summary:
In an acute oral toxicity study performed according to OECD TG 423 a single oral dose of 2000 mg/kg bw was tolerated withouth mortalities, clinical signs, effects on weight gain and gross pathological findings. Thus, the LD50 was determined for the substance with > 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
