Registration Dossier
Registration Dossier
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EC number: 201-696-0 | CAS number: 86-74-8
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Acute aquatic data is available for fish, daphnia and algae, all studies showing methodological and documentary deficiencies, hence the majority of them considered to be of reliability 3:
In one 96h exposure study on fish, the LC50 values were found to be 0.93 mg/L (analytical) under flow-through conditions and about 1.3 mg/L (analytical) under static conditions, respectively, both at the margin of the maximum water solubility of carbazole. All other concentrations below failed to produce signs of intoxication in this investigation (Brooke 1991).
It is suggestive that the presence of acetonitrile as auxilliary agent biassed the inherent properties of carbazole. Due to the limited documentation, no firm conclusion about the validity of this result can be drawn.
A second study in fish, the LC50(48 h) was found in a semi-static study using carp at 2.5 mg/L, while in two studies on daphnia the EC50 were very similar at about 3.2 mg/L (analytical).
The lowest NOEC was 0.4 mg/L (analytical) in algae; no EC50 value was derivable in this study. In a second algal study, the EC50(72 h) was far above water solubility.
Overall, the results indicate that, in general, the EC50/LC50 values are above the maximum water solubility of about 1 mg/L.
The relevant average LC50 derived from the results of Brooke (1991) is considered to be 1.1 mg/L.
Conclusion on classification
No classification as to aquatic toxicity is indicated, since - based on the weight of evidence - EC50/LC50 values for carbazole are found to be above water solubility.
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