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EC number: 258-004-5 | CAS number: 52556-42-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 July 2012 - 13. September 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 3-(allyloxy)-2-hydroxypropanesulphonate
- EC Number:
- 258-004-5
- EC Name:
- Sodium 3-(allyloxy)-2-hydroxypropanesulphonate
- Cas Number:
- 52556-42-0
- Molecular formula:
- C6H12O5S.Na
- IUPAC Name:
- sodium 2-hydroxy-3-(prop-2-en-1-yloxy)propane-1-sulfonate
- Reference substance name:
- Sodium hydroxide
- EC Number:
- 215-185-5
- EC Name:
- Sodium hydroxide
- Cas Number:
- 1310-73-2
- Molecular formula:
- HNaO
- IUPAC Name:
- sodium hydroxide
- Reference substance name:
- 3-(allyloxy)propane-1,2-diol
- EC Number:
- 204-620-4
- EC Name:
- 3-(allyloxy)propane-1,2-diol
- Cas Number:
- 123-34-2
- Molecular formula:
- C6H12O3
- IUPAC Name:
- 3-(allyloxy)propane-1,2-diol
- Reference substance name:
- disodium 2-hydroxy-3-(3-sulfonatopropoxy)propane-1-sulfonate
- Molecular formula:
- C6H12Na2O8S2
- IUPAC Name:
- disodium 2-hydroxy-3-(3-sulfonatopropoxy)propane-1-sulfonate
- Test material form:
- solid: particulate/powder
- Details on test material:
- light yellow powder
Constituent 1
additive 1
impurity 1
impurity 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Environmental conditions
Healthy femal rats were housed by group of three in solid bottomed clear polycarbonates cages.
Temperature 19 - 25° C
Relative humidity 30 - 70 %
Food and drinking
Drinking water and foodstuff were supplied freely. Food was removed on D-1 and then redistributed 4 hours after the test item administration.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 300 mg/kg bw/day and 2000 mg/kg bw/day
- No. of animals per sex per dose:
- 6 rats (female) per dose
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality occured in animals dosed at 300 mg/kg bw and 2000 mg/kg bw.
- Clinical signs:
- other: Dose: 300 mg/kg bw No clinical signs related to the adminsitration of the test item were observed during the study. Dose: 2000 mg/kg bw A decrease in spontaneous activity (3/) and piloerection (3/6) were noted at 1 hour post-dose.
- Gross pathology:
- The macroscopic examination of the animal at the end of the study did not reveal treatment related changes.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD 50 of the test item is higer than 2000 mg/kg body weight by oral route in the rat.
In accordance with the OECD guideline No. 423, the LD50 cut off-of the test item may be considered higher than 5000 mg/kg body weight by oral route in the rat.
According to the criteria of classification , packaging and labelling of dangerous substances and preparation in accordance with the ECC Directives 67/548, 2001/59 and 99/45, the test item does not have to be classified. No symbol or risk phrase is required.
In accordance with the regulation EC No. 1272/2008 on classification, labelling and packaging of substances and mixtures, the test item does not have to be classified. No signal word or hazard satement is requird. - Executive summary:
The test item was administrated to a group of 6 female Sprague Dawley rats at a single dose of 300 mg/kg body weight ans then, to a group of 6 female sprague Dawley rats at the single dose of 2000 mg/kg body weight. The experimental protocol was established according to the official method as defined in the OECD guideline No. 423 dated December 17th, 2001 and the test method B.1 tris of the council regulation No. 440/2008.
No mortality occured in animals dosed at 300 mg/kg body weight.
No clinical signs related to the adminsitration of the test item were observed during the study.
No body weight evolution of hte animal remained normal throughout the study.
The macroscopic examination of the animal at the end of the study did not reveal treatment related changes.
No mortality occured in animals dosed at 2000 mg/kg body weight.
A decrease in spontaneous activity (3/) and piloerection (3/6) were noted at 1 hour post-dose.
No body weight evolution of hte animal remained normal throughout the study.
The macroscopic examination of the animal at the end of the study did not reveal treatment related changes.
In conclusion, the LD 50 of the test item is higer than 2000 mg/kg body weight by oral route in the rat.
In accordance with the OECD guideline No. 423, the LD50 cut off-of the test item may be considered higher than 5000 mg/kg body weight by oral route in the rat.
According to the criteria of classification , packaging and labelling of dangerous substances and preparation in accordance with the ECC Directives 67/548, 2001/59 and 99/45, the test item does not have to be classified. No symbol or risk phrase is required.
In accordance with the regulation EC No. 1272/2008 on classification, labelling and packaging of substances and mixtures, the test item does not have to be classified. No signal word or hazard satement is requird.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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