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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms


Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.26 mg/L
Assessment factor:
Extrapolation method:
assessment factor

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.026 mg/L
Assessment factor:
Extrapolation method:
assessment factor


Hazard assessment conclusion:
no hazard identified

Sediment (freshwater)

Hazard assessment conclusion:
no hazard identified

Sediment (marine water)

Hazard assessment conclusion:
no hazard identified

Hazard for air


Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms


Hazard assessment conclusion:
PNEC soil
PNEC value:
0.12 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Hexan-1-ol (CAS 111-27-3) is highly water soluble (5900 mg/l at 23˚C), and has low log Kow (2.03). It has no hydrolysable structural features and would be expected to be stable in water. It is very rapidly biodegradable.

Hexan-1-ol is a member of a category of long chain aliphatic alcohols (LCAAs) with a carbon chain length range of C6-C24. The Category is limited to linear and essentially-linear aliphatic alcohols.

As carbon number increases, short- and long-term aquatic toxicity generally increase (i.e. decreasing E(L)C50 and NOEC values observed) up to a threshold carbon number, above which there are no effects at the limit of solubility. For short term effects the threshold is between C13 and C14; for chronic effects it is between C15 and C16. The observed threshold in carbon number is associated with limitations on the degree to which predictable effects are expressed at the limit of solubility, which is low for the longer-chain alcohol structures in the category.

Evidence across the Category of C6-24 long-chain aliphatic alcohols (LCAAs) supports the conclusion that a similar level of susceptibility is exhibited for all three taxonomic groups in the short-term data set.


Alcohols in the Category have toxicity consistent with non-polar narcosis effects, in line with the very many organic non-polar narcotic organic substances that have been extensively studied and described in literature by various authors. Therefore the LCAAs in this category should be considered in the context of neutral organics.

Long-term toxicity testing across the category has been carried out with fish and Daphnia. However, significant biodegradation losses of substance in the test system still occurred, despite measures taken to prevent this. A full report detailing properties and trends across the LCAAs category, as well as further discussion on measures to prevent test substance losses is available: ECOTOXICITY Alcohols C6-24 Category report.

There are no measured long-term data for Hexan-1-ol. Quantitative structure-activity relationships ((Q)SAR’s) for estimating NOECreproduction in Daphnia have been developed. It is possible to apply these relationships to predict long-term toxicity endpoints for other members of the Category. Further details are described in the ECOTOXICITY Alcohols C6-24 Category report.

Reduced assessment factors have been used to derive PNECs:

Basis for setting of assessment factor 

The purpose of assessment factors is to take a laboratory result and estimate a PNEC that applies to the environment itself. In summary, and as is well-known, the purpose of the factors is to account for uncertainty in:

1.     Intra-laboratory variability

2.     Inter-laboratory variability

3.     Duration

4.     Sensitivity of the environmental ecosystem relative to the range or organisms actually tested.  

For one substance standing alone, the factor of 10 is considered in the Guidance to apply to three long term NOECs or ECx values for the aquatic compartment. Similarly an assessment factor of 50 is specified when deriving a PNEC when two long-term NOECs or EC10s for different taxonomic groups are available.  

Why is the Guidance default of 10 a reasonable number for long-term data? A reasoned discussion is set out in the table below, along with an application of the same logic to hexan-1-ol.  

Table 1 A basis of understanding assessment factors and application to long-term studies with alcohols  


General rationale when three trophic levels have been studied

Members of the C6-24 Alcohols Category

1. Intra-laboratory variability


For well-performed studies with good chemical analysis point 1 is negligible

This applies.

Use 1

2. Inter-laboratory variability

A factor of 2 to 5 would be realistic

For the long-chain alcohols, the inter-laboratory variation is much lower, because the substances are archetypal exemplars of non-polar narcotics.

Use 2

3. Duration


When a full set of long-term NOECs or ECxvalues are available, the contributing factor associated with point 3 (duration) is relatively minor, and can be ignored.

This is definitely the case for the ecosystem, in which alcohols are ubiquitous, so duration is irrelevant.

Use 1

4. Sensitivity of the environmental ecosystem

For point 4 (ecosystem sensitivity), a value of 2 to 5 is realistic

For non-polar narcotics, many species of organism have been studied, so the uncertainty regarding lab to field extrapolation should also be reduced. The ecosystem is adapted to alcohols.

Suggest 2.5


The geometric mean of the range of the two contributing factors is 10. Whilst not set out in Guidance, such a breakdown is a reasonable basis of the factors and is consistent with such extrapolations in mammalian toxicology.

AF = 1*2*1*2.5 = 5 is implied


Although in the case of hexan-1-ol specifically, a full set of long-term results are not available, the predictability of trends across the category, the low acute-to-chronic ratio and the potential for metabolism mean that the duration factor (point 3) does not need to be inflated. On the basis of this logic, an assessment factor of 10 is very conservative for deriving PNECs in the chemical safety assessment of this substance. However, an assessment factor of 10 has been applied to the lowest NOEC or ECx value to derive aquatic PNECs.

For further discussion please refer to the attached ECOTOXICITY Alcohols C6-24 Category report.

Conclusion on classification

Hexan-1-ol has reliable short-term E(L)C50 values for fish, invertebrates and algae of 97 mg/l, 201 mg/l and 79.7 mg/l, respectively. It has a reliable NOEC of 11.3 mg/l in algae and a reliable predicted 21-d NOEC of 6.8-13 mg/l in Daphnia. The substance is readily biodegradable and very rapidly biodegraded in non-sterilised systems.  

These data are consistent with the following classification under Regulation (EC) No 1272/2008 (as amended) (CLP):

Acute toxicity: Not classified.

Chronic toxicity: Not classified