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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
December 1992
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
March 1989
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Version / remarks:
August 1996
Deviations:
no
Principles of method if other than guideline:
NA
GLP compliance:
no
Type of method:
other: calculation (Leo-Hansch method)
Partition coefficient type:
octanol-water
Analytical method:
other: theoretical calculation
Key result
Type:
log Pow
Partition coefficient:
> 6
Temp.:
20 °C
Remarks on result:
other: calculation

As Urea 4 consists of several constituents, for each constituent a partition coefficient was calculated. The partition coefficients (log Pow values) of all possible constituents are > 6.

Conclusions:
The partition coefficient of Urea 4 was estimated to be log Pow > 6 using the Leo-Hansch method.
Executive summary:

The partition coefficient of Urea 4 was estimated according to EU method A.8 (Leo-Hansch method), OECD Guideline 117, and EPA OPPTS 830.7570 guideline. The partition coefficient of Urea 4 was estimated to be log Pow > 6 using the Leo-Hansch method. Urea 4 was not soluble in n-octanol and only slightly soluble in water. Therefore, due to the low solubility of Urea 4 in water and n-octanol and the low sensitivity of the analytical methods available the experimental determination of the partition coefficient by any analytical technique was technically not feasible.

Description of key information

The partition coefficient of Urea 4 was estimated to be log Pow > 6 using the Leo-Hansch method.

Key value for chemical safety assessment

Log Kow (Log Pow):
6
at the temperature of:
20 °C

Additional information

The partition coefficient of Urea 4 was estimated according to EU method A.8 (Leo-Hansch method), OECD Guideline 117, and EPA OPPTS 830.7570 guideline. The partition coefficient of Urea 4 was estimated to be log Pow > 6 using the Leo-Hansch method. Urea 4 was not soluble in n-octanol and only slightly soluble in water. Therefore, due to the low solubility of Urea 4 in water and n-octanol and the low sensitivity of the analytical methods available the experimental determination of the partition coefficient by any analytical technique was technically not feasible.