C16-18-(even numbered)-alkyl fatty acid, compound with C16-18-(even numbered)-alkylamine

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was performed according to OECD 105 Guideline (adapted for n-Octanol)

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2009

Reference 2

Reference Type:

other company data

Title:

Unnamed

Report date:

2010

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD 105

Deviations:

yes

Remarks:

adapted for n-Octanol

Principles of method if other than guideline:

For substances that are completely miscible with octanol, the numerical value of the octanol solubility should be derived from the density. Together with the water solubility this can be used to estimate logP values. The method is not applicable to substances that are completely miscible with both water and octanol.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

(Z)-octadec-9-enylamine

EC Number:

204-015-5

EC Name:

(Z)-octadec-9-enylamine

Cas Number:

112-90-3

Molecular formula:

C18H37N

IUPAC Name:

(Z)-octadec-9-en-1-amine

Details on test material:

- Name of test material (as cited in study report):Oleylamine

Results and discussion

Solubility in organic solvents / fat solubility

Key result

Medium:

n-octanol

Solubility:

813 g/L

Temp.:

25 °C

Remarks on result:

other: since the substance is miscible at every ratio, the solubility is presented as the density of the pure substance

Test substance stable:

yes

Details on results:

Solubility of octadec-9-en-1-amine in n-octanol is 813 g/L.

Any other information on results incl. tables

Following mixtures of oleylamine and n-octanol were prepared at room temperature (23 °C):

10 ml n-octanol + 1 ml oleylamine: clear solution

10 ml n-octanol + 10 ml oleylamine: clear solution

5 ml n-octanol + 10 ml oleylamine: clear solution

1 ml n-octanol + 10 ml oleylamine: clear solution

Applicant's summary and conclusion

Conclusions:

From this result it can be concluded that oleylamine and n-octanol are miscible at every ratio. Thus, the density is used as the maximum solubility in n-Octanol.

The thermodynamics of solutions usually works with concentrations expressed as amount of substance per unit volume of solution. In the case of complete miscibility, the maximum concentration is the pure substance. As a result the numerical value of the solubility is given by the density expressed in g/L.

Executive summary:

The solubility of the test substance tetradecylamine in n-octanol was determined according to the OECD TG 105, using the shake-flask method. Solubility in n-octanol is 813 g/L.