Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-653-9 | CAS number: 98-29-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Little information is available about the test conditions and the results. No information about the test substance purity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 952
- Report date:
- 1952
Materials and methods
- GLP compliance:
- no
- Test type:
- other: comparison of vapors evolved from the solid at room temperature and at 170°C
Test material
- Reference substance name:
- 4-tert-butylpyrocatechol
- EC Number:
- 202-653-9
- EC Name:
- 4-tert-butylpyrocatechol
- Cas Number:
- 98-29-3
- Molecular formula:
- C10H14O2
- IUPAC Name:
- 4-tert-butylbenzene-1,2-diol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: no
- No. of animals per sex per dose:
- 6
Results and discussion
- Other findings:
- Six rats were exposed, in a 9 liter chamber, to air that had been passed at 2.5 liters per minute through a 100 ml burette loosely packed with 50 grams of p-t-butyl catechol and glass wool. None of the rats died as the result of an 8-hour exposure.
A mist, prepared by heating 50 grams of the compound to 170°C in a gas-washing bottle while air was passed through the fritted glass disc immersed therein, was lethal to 6 rats exposed for 1 hour while only 1 of 6 died in a similar 30-minute exposure. This compound is a solid at room temperature, but after heating at 170°C for 30 minutes it becomes and remains a viscous dark liquid at room temperature.
Applicant's summary and conclusion
- Conclusions:
- Vapors evolved at room temperature would not be hazardous but the vapor and aerosol produced by heating is definitely hazardous to life.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
