Registration Dossier
Registration Dossier
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EC number: 202-424-3 | CAS number: 95-49-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Groups of 3 male and 3 female rats were given one intraperitoneal injection of 2.70, 1.35 or 0.68 g/kg and one group of 3 females was given 5.42 g/kg and the survivors observed for 7 days.The mortality was recorded, a gross and microscopical pathological examination was done.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chlorotoluene
- EC Number:
- 202-424-3
- EC Name:
- 2-chlorotoluene
- Cas Number:
- 95-49-8
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 1-chloro-2-methylbenzene
- Details on test material:
- purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: young adult Alderly Park strain
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: inert dispersing medium
- Doses:
- 680, 1350, 2700, 5420 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 680 - < 1 350 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 2 700 - < 5 420 mg/kg bw
Any other information on results incl. tables
Immediately after dosing all animals showed signs of severe abdominal irritation and loss of muscle control. They became comatose on the higher doses and semi-comatose on the lower dosage. All dead animals showed signs of peritonitis. The surviving animals recovered from coma within 48 hours and showed signs of abdominal irritation during the test. They did not gain weight nomally. At autopsy all animals showed signs of peritonitis (some severe) and this was confirmed microscopically. Reduced spermatogenesis was noted in two males and all animals given 680 mg/jk bw showed and increase in mitosis of liver cells.
Applicant's summary and conclusion
- Executive summary:
Groups of 3 male and 3 female rats were given one intraperitoneal injection of 2.70, 1.35 or 0.68 g/kg and one group of 3 females was given 5.42 g/kg and the survivors observed for 7 days.The mortality was recorded, a gross and microscopical pathological examination was done.
LD50 = 680 -1350 mg/kg (rat, male, ip), LD50 = 2700 -5420 mg/kg bw (rat, female, ip)
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