Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-820-9 | CAS number: 110-97-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1´-iminodipropan-2-ol
- IUPAC Name:
- 1,1´-iminodipropan-2-ol
- Reference substance name:
- 1,1'-iminodipropan-2-ol
- EC Number:
- 203-820-9
- EC Name:
- 1,1'-iminodipropan-2-ol
- Cas Number:
- 110-97-4
- Molecular formula:
- C6H15NO2
- IUPAC Name:
- 1,1'-iminodipropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Diisopropanolamin asymmetrisch
- Lot/batch No.: 7752
- Purity: 99.261% (GC)
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: DR. K. THOMAE GMBH
- Age at study initiation: young adult animals
- Weight at study initiation: 150 - 300 g
- Fasting period before study: 16 h before administration
- Housing: single housing
- Diet: Kliba-Labordiaet 343, Klingenthalmuehle AG, CH-4303 Kaiseraugust, ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24°C
- Humidity (%): 30-70 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Justification for choice of vehicle: The test substance is insoluble in aqua bidest
- Concentration in vehicle: 20 or 40 g/100 ml for the 1000 or 2000 mg/kg bw dose, respectively
- Amount of vehicle: 5 ml/kg bw - Doses:
- 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Twice each workday and once on weekends
- Frequency of weighing: Individual body weights shortly before application (day 0), weekly thereafter and at the end of the study.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- No statistics needed
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality occured.
- Clinical signs:
- other: No symptoms were observed.
- Gross pathology:
- No abnormalities were noted at necropsy of animals sacrificed at the end of the study.
Any other information on results incl. tables
Mean body weights.
| male | female | ||||
| Dose | 1000 mg/kg | 2000 mg/kg | 1000 mg/kg | 2000 mg/kg | |
| day 0 (before application) | 181 | 200 | 189 | 188 | |
| day 7 | 248 | 264 | 220 | 215 | |
| day 12 | 273 | - | 224 | - | |
| day 13 | - | 301 | - | 226 | |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
