Registration Dossier
Registration Dossier
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EC number: 203-820-9 | CAS number: 110-97-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 08. Jan 1965 - 08. Feb 1965
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Due to the low vapour pressure, the technically highest attainable concentration is approximately 0.11 g/m3 (20 ppm) when the test substance is evaporated at 20°C (concentration not determined), which is far below any limit concentration.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- BASF-Test: Test was performed in principle as described in OECD Guideline 403.
The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20°C). Three rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8h. The documentation of clinical signs was performed over a period of 7 days. In order to verify the results, the test was repeated once. - GLP compliance:
- no
- Test type:
- other: BASF-test
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1´-iminodipropan-2-ol
- IUPAC Name:
- 1,1´-iminodipropan-2-ol
- Reference substance name:
- 1,1'-iminodipropan-2-ol
- EC Number:
- 203-820-9
- EC Name:
- 1,1'-iminodipropan-2-ol
- Cas Number:
- 110-97-4
- Molecular formula:
- C6H15NO2
- IUPAC Name:
- 1,1'-iminodipropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Diisopropanolamin
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 214 g (mean)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- 12
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observations
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- other: saturated DIPA atmosphere (concentration not given)
- Exp. duration:
- 8 h
- Mortality:
- no mortality occured
- Clinical signs:
- other: no abnormalities observed
- Body weight:
- Weight at study inition: 214 g (mean)
Weight at study termination: 242 g (mean) - Gross pathology:
- no abnormalities observed
Applicant's summary and conclusion
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