Thionyl dichloride

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

other: read-across from the hydrolysis product of SOCl2 (SO2)

Adequacy of study:

key study

Study period:

Not specified; published in 1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Purity and source of test material was not given; individual animal data are not reported; study was not GLP. Study however used an accepted OECD method, without methodological deficiency.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1985

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Version / remarks:

(1981)

Deviations:

no

Principles of method if other than guideline:

Not applicable.

GLP compliance:

no

Remarks:

GLP was not compulsory at the time the study was conducted

Test material

Test material information

Constituent 1

Reference substance name:

Hydrogen chloride

EC Number:

231-595-7

EC Name:

Hydrogen chloride

Cas Number:

7647-01-0

IUPAC Name:

chloride

Details on test material:

Hydrochloric acid aqueous solution at 37%.
No further details specified.

Test animals

Species:

other: rabbit (Albino)

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Sex: males and females
- Source: obtained from various breeders
- Age at study initiation: adult
- Weight at study initiation: 2-4 kg
- Housing: not specified
- Diet (e.g. ad libitum): not specified
- Water (e.g. ad libitum): not specified
- Acclimation period: not specified


ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified
- Humidity (%): not specified
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): not specified


IN-LIFE DATES: From: Not specified

Test system

Type of coverage:

other: occlusive and semi-occlusive method was used.

Preparation of test site:

shaved

Vehicle:

water

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL aqueous solution
- Concentration (if solution): 370 g/L in water

VEHICLE
No details specified

Duration of treatment / exposure:

Either 1 or 4 hrs

Observation period:

1, 24, 48, 72 and 7 days after removal of patches.

Number of animals:

6 per group

Details on study design:

TEST SITE
- Area of exposure: 3x3 cm
- % coverage: not specified

0.5 mL of aqueous solution was applied to gauze pads (3x3 cm). The patches were fixed on the prepared skin areas of the flank and covered by wrapping either an air-permeable circular bandage (semi-occlusive method) or air tight plastic foil (occlusive method) around the animals.

Dorsal and lateral parts of the trunk were clipped 15-24 hr prior to exposure. Only animals with healthy and uninjured skin were used. Four patches were applied dorsally (laterally) to each animal.

REMOVAL OF TEST SUBSTANCE
Yes, after removal of the patches the treated skin areas were rinsed with water and dried.

SCORING SYSTEM
Evaluation of erythema, oedema and eschar formation.
According to OECD 404 (1981).

Results and discussion

In vivo

Irritant / corrosive response data:

HCl applied as an aqueous solution at a percentage of 37% proved to be corrosive to the rabbit skin.
Results are reported in "Remarks on results including tables and figures".

Other effects:

Not stated.

Any other information on results incl. tables

HCl applied as an aqueous solution proved to be corrosive at a percentage of 37%.

1 hr exposure		4 hrs exposure
Semi-occlusive	Occlusive	Semi-occlusive	Occlusive
Corrosive	Corrosive	Corrosive	Corrosive

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: not specified

Conclusions:

HCl applied as an aqueous solution at a percentage of 37% was corrosive to the rabbit skin.