Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-234-8 | CAS number: 79-92-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Analogue approach: The target substance Camphene and the source substance 5-ethylidenebicyclo[2.2.1]hept-2-ene share the same organic functional group (cycloalkene).
Data source
Reference
- Reference Type:
- other: read-across
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- The reporting form for analogue approach is attached.
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 5-ethylidene-8,9,10-trinorborn-2-ene
- EC Number:
- 240-347-7
- EC Name:
- 5-ethylidene-8,9,10-trinorborn-2-ene
- Cas Number:
- 16219-75-3
- IUPAC Name:
- 5-ethylidenebicyclo[2.2.1]hept-2-ene
- Details on test material:
- - Name of test material (as cited in study report): 5-ethylidenebicyclo[2.2.1]hept-2-ene
- Molecular formula (if other than submission substance): C9H12
- Molecular weight (if other than submission substance): 120.19
- Smiles notation (if other than submission substance): C1(\[C@@H]2C[C@@H](C1)C=C2)=C\C
- InChl (if other than submission substance): InChI=1/C9H12/c1-2-8-5-7-3-4-9(8)6-7/h2-4,7,9H,5-6H2,1H3/b8-2+
- Structural formula attached as image file (if other than submission substance): see attached illustration.
Constituent 1
Test animals
- Species:
- other: rat and mouse
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
The analogue 5-ethylidenebicyclo[2.2.1]hept-2-ene which shares the same functional group with Camphene, also has comparable values for the relevant molecular properties. These properties are:
- log Pow value which is 3.67 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.22 for Camphene,
- water solubility which is 15.91 mg/l at 25 ºC for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.2 mg/l for Camphene at 20 º C and
- similar molecular weights which are 120.19 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 136.23 for Camphene.
The reporting form for analogue approach is attached.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 for the substance 5-ethylidenebicyclo[2.2.1]hept-2-ene is greater than 2000 mg/kg bw. Based on the read-across approach, the oral LD50 for the substance Camphene is also greater than 2000 mg/kg bw.
- Executive summary:
The analogue 5-ethylidenebicyclo[2.2.1]hept-2-ene which shares the same functional group with Camphene, also has comparable values for the relevant molecular properties. These properties are:
- log Pow value which is 3.67 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.22 for Camphene,
- water solubility which is 15.91 mg/l at 25 ºC for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.2 mg/l for Camphene at 20 º C and
- similar molecular weights which are 120.19 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 136.23 for Camphene.
The oral LD50 for the substance 5-ethylidenebicyclo[2.2.1]hept-2-ene is greater than 2000 mg/kg bw. Based on the read-across approach, the oral LD50 for the substance Camphene is also greater than 2000 mg/kg bw.
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