Registration Dossier
Registration Dossier
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EC number: 217-168-8 | CAS number: 1761-71-3
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity data are available for fish, invertebrates, algae and cyanobacteria and micro-organisms.
The short-term 96 -h LC50 for fish (Leuciscus idus) was > 100 mg/L (nominal concentration, pH-adjusted test solution; BASF AG, 1988, report no. 10F0562/875273); the study also reported a 96 -h LC50 of 67.8 mg/L from the results of a series of non-pH-adjusted test solutions (nominal; geometric mean; not pH-adjusted). The mortality was significantly reduced after pH-adjustment.
The short-term EC50 for invertebrates (Daphnia magna) was 7.64 mg/L (geometric mean of three studies: BASF AG 1989; report no. 1/0021/2/89 -0021/89; APC, 2002a and 2002b, report no. RRRS EXT-02/055).
The ErC50 for aquatic algae and cyanobacteria (Desmodesmus subspicatus) was > 141.2 mg/L (BASF AG, 1990, report no. 01/89/0021) for non-pH-adjusted test solutions.
A short-term respiration inhibition study according to ISO 8192 with domestic activated sludge was conducted with the chemical analogue DMDC. After 30 minutes an EC20 of 160 mg/l was determined (BASF AG, 1990; report no. 01/89/2152)
The EC10 for micro-organisms was 80 mg/L based on the results of test on inhibition of oxygen consumption of Pseudomonas putida (BASF AG, 1987; report no. 01/87/0792).
Therefore, invertebrates (Daphnia magna) were identified as the most sensitive group of aquatic organisms.
Long-term aquatic testing of fish was not conducted with PACM. An ACR approach according to ECETOC No. 91 (2003) for fish results in an indication of a chronic NOEC greater than 1 mg/L.
The ErC10 for aquatic algae and cyanobacteria (Desmodesmus subspicatus) was ~100 mg/L (BASF AG, 1990, report no. 01/89/0021) for non-pH-adjusted test solutions.
The NOEC for aquatic invertebrates of 4.0 mg/L was based on the 21 d-reproduction inhibition from the key study on Daphnia magna with the structural analogue DMDC (NITE Japan, 2003; NMMP/E00/3090).
The chronic NOEC for Daphnia magna was the point of departure for the derivation of the PNECaquatic(freshwater) and PNECaquatic(marine water)and PNECaquatic(intermittent releases). The acute EC50 for Daphnia magna was the point of departure for the derivation of the PNECaquatic(intermittent releases). The EC20 from a respiration inhibition study was the point of departure for the derivation of the PNECSTP.
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