Registration Dossier
Registration Dossier
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EC number: 201-280-9 | CAS number: 80-46-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The most reliable study result for the test substance has been identified as a study (Holcombe et al. 1984) which reports an LC50 for short term toxicity in fish of 2.5 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.5 mg/L
Additional information
Reliable (Klimisch 1 or 2) short-term toxicity studies with fish have been conducted for p-tert-amylphenol and are included in this dossier.
Holcombe et al. (1984) conducted a reliable (Klimisch 1) study following methods similar to OECD 203. Fathead minnows (Pimephales promelas) 31-35 days old, were exposed to measured concentrations of p-tert-amylphenol in a flow-through system for 96 hours. The 96-hr LC50, based on mortality, was 2.5 mg/L.
Davoren and Fogarty (2005) conducted a reliable (Klimisch 2) study according to OECD 203 with sodium p-tert-amylphenol. Data obtained from tests using the salt is assumed to be representative of the parent substance due to its weak acid properties. Rainbow trout (Oncorhynchus mykiss) fry, were exposed to nominal concentrations (0.18-10.0 mg/L) of the test substance for 96 hours. The 96-hr LC50, based on mortality, for rainbow trout was 1.0 mg/L.
Broderius et al (1995) conducted a reliable (Klimisch 1) study following methods similar to OECD 203 with p-tert-amylphenol. Juvenile fathead minnows (Pimephales promelas) were exposed to the concentrations of the test substance for 96 hours. The 96-hr LC50, based on mortality, was 2.59 mg/L.
Gimeno et al. (1998) conducted a reliable (Klimisch 2) study with p-tert-amylphenol. Common carp (Cyprinus carpio), 0.5-1.1 g, were exposed to measured concentrations (nominal 0, 0.56, 0.75, 1.0, 1.3, 1.8, 2.4, and 3.2 mg/L) of the test substance in a static test for 96 hours. The 96-hr LC50, based on mortality, was 1.6 mg/L.
Hagino et al.( 2001) conducted a study (Klimisch 3) where adult medaka (Oryzias latipes) were exposed to p-tert-amylphenol for 96 hours. The 96-hr LC50, based on mortality, was 2.6 mg/L. Although the study was not conducted according to acceptable methods, it is presented here for comparison.
SafePharm (1992) conducted a study (Klimisch 2) using p-tert-amylphenol as the test substance. Rainbow trout (Oncorhynchus mykiss) 4.4cm long, were exposed to nominal concentrations of the test substance for 96 hours. The 96-hr LC50, based on mortality, was >1.0 mg/L.
Adequate reliable measured data exists for short-term toxicity to fish for p-tert-amylphenol and has been documented within this dossier. The most reliable study result for the test substance has been identified as a study (Holcombe et al. 1984) which reports an LC50 for short term toxicity in fish of 2.5 mg/L. Consequently this value will be taken as the short-term toxicity in fish endpoint for p-tert-amylphenol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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