Zinc bis(2-ethylhexanoate)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; post exposure observation period 7 days; low number of rats)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1996

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

Inhalation hazard test

Deviations:

no

GLP compliance:

no

Test type:

other: Inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexanoic acid

EC Number:

205-743-6

EC Name:

2-ethylhexanoic acid

Cas Number:

149-57-5

Molecular formula:

C8H16O2

IUPAC Name:

2-ethylhexanoic acid

Details on test material:

Name of test material (as cited in study report): alpha-Aethylhexansaeure
- Physical state: liquid
- Analytical purity: ca. 99%

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Rats exposed for 8 h, respectively, to a vapour saturated atmosphere. Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder. The glas cylinder was heated in a water bath. Temperature in the exposure chamber was 20°C. Concentration was stated in the raw data to be 0.11 mg/l. this was calculated based on the substache loss. Base on a vapor pressure 0f 0.04 mbar and a molecular weight of 144,21 saturated vapor concentration of 2-Ethylhexanoic acid is 0.24 mg/l. Concentration of 0.11 mg/l may be regarded as reliable therfore

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

0.11 mg/l (nominal)

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days

Statistics:

not necessary

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.11 mg/L air (nominal)

Exp. duration:

8 h

Remarks on result:

other: inhalation hazard test

Mortality:

No Mortality was observed.

Clinical signs:

other: no clinical signs were noted

Body weight:

no data

Gross pathology:

no substance related findings. In one animal bronchitis was detected.

Any other information on results incl. tables

The inhalation risk test demonstrates that there is no hazard from 2 -ethylhexanoic acid to be expected at room temperature.