Registration Dossier
Registration Dossier
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EC number: 203-213-9 | CAS number: 104-55-2
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: GD6475000
- Year:
- 2 012
- Bibliographic source:
- RTECS(Registry of Toxic Effects of Chemical Substances); Munksgaard International Pub.CODEDG Contact Dermatitis.Environmental and Occupational Dermatitis.(Munksgaard International Pub.,c/o Publications Expediting Inc., 200 Meacham Ave.,Elmont,NY 1100;2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cinnamaldehyde
- EC Number:
- 203-213-9
- EC Name:
- Cinnamaldehyde
- Cas Number:
- 104-55-2
- Molecular formula:
- C9H8O
- IUPAC Name:
- 3-phenylacrylaldehyde
- Details on test material:
- - Name of test material (as cited in study report): cinnamaldehyde
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 3D (intermittent)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
750 mg/kg/3D (intermittent)
Basis:
no data
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 750 other: mg/kg/3D (intermittent)
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Toxic effect : Skin and Appendages - cutaneous sensitization, experimental (after topical exposure)
Applicant's summary and conclusion
- Conclusions:
- The LOAEL (lowest observed adverse effect level) value for cinnamaldehyde was found to be 750 mg/kg/3D (intermittent) in mouse for 3 days.
- Executive summary:
The LOAEL (lowest observed adverse effect level) value for cinnamaldehyde was found to be 750 mg/kg/3D (intermittent) in mouse for 3 days.
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