Allyl 2,3-epoxypropyl ether

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given, acceptable with restrictions (The study was performed before the establishment of GLP and OECD guidelines.)

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1978

Materials and methods

Principles of method if other than guideline:

Six male rats per dose group were exposed to the nominal concentrations of 100, 250, 300, 375 and 500 ppm allyl glycidyl ether vapor. All rats were observed for signs of toxicity and LC50 was calculated.

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Allyl 2,3-epoxypropyl ether

EC Number:

203-442-4

EC Name:

Allyl 2,3-epoxypropyl ether

Cas Number:

106-92-3

Molecular formula:

C6H10O2

IUPAC Name:

2-[(prop-2-en-1-yloxy)methyl]oxirane

Details on test material:

- Name of test material (as cited in study report): allyl glycidyl ether

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Sparta Research Animals, Inc., Michigan

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

not specified

Details on inhalation exposure:

no data

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

100, 250, 300, 375, 500, 700, 1175 and 2600 ppm (equivalent to 0.47, 1.18, 1.42, 1.78, 2.37, 3.32, 5.57 and 12.31 mg/l) Calculation of concentrations (mg/L) based on Derelanko MJ (2000). Toxicologist's Pocket Handbook, CRC Press, conversion table, p. 57.

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

ca. 1.46 mg/L air

95% CL:

1.36 - 1.6

Exp. duration:

7 h

Mortality:

0/6, 0/6, 2/6, 6/6, 6/6, 6/6, 6/6 and 6/6 rats died in the dose levels of 100, 250, 300, 375, 500, 700, 1175 and 2600 ppm groups, respectively. In the 300 ppm group, 2 rats died within 24h of exposure. In the 375 ppm group, 2 rats died within 24 h, 2 died within 48 h and rest 2 died within 72h of exposure. In the 500 ppm group, all rats died within 24 h of exposure.

Clinical signs:

other: During exposure to the rats of top 3 exposed groups were gasping and had exudates around the nose and mouth. Slight nasal irritation and slight gasping were observed in rats of the 100 ppm group during exposure. These signs of toxicity occurred with incre

Gross pathology:

Rats of the 700 ppm group were found to have a distended stomach from gasping, and hyperemic nasal turbinates; rats of the 1175 ppm group had dark and congested lungs; rats of the 2600 ppm group exhibited the above signs of toxicity, in addition to congested livers, hydrothorax, and paleness of the cortex of the kidneys with an accentuated corticomedullary junction. No visible lesions were found upon gross pathological examination of rats of the 100 and 250 ppm groups. However, rats of the 300, 375, and 500 ppm groups had nasal exudate, nasal turbinates which were congested and edematous, a distended stomach from gasping, and corneal cloudiness. Congested livers and kidneys were also observed in rats of the 300 and 375 ppm groups, while rats of the 500 ppm group had lungs which were congested, hyperemic, and edematous.

Any other information on results incl. tables

The LC50 (7h exposure) was reported to be 308 ppm (287 -338 ppm) which is equivalent to approximately 1.46 mg/l (1.36 -1.6 mg/l).

The LC50 (4h exposure) = 1.46 x 1.75 = 2.56 mg/l