Registration Dossier
Registration Dossier
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EC number: 228-408-6 | CAS number: 6259-76-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- predates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hexyl salicylate
- EC Number:
- 228-408-6
- EC Name:
- Hexyl salicylate
- Cas Number:
- 6259-76-3
- Molecular formula:
- C13H18O3
- IUPAC Name:
- hexyl salicylate
- Details on test material:
- - Name of test material (as cited in study report): Hexyl salicylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 10 animals/dose
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- Not required
Results and discussion
- Preliminary study:
- Not relevant
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1/10 rats died
- Clinical signs:
- other: Urinary incontinence was observed at 24 hours
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
No additional information
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 in rats was greater than 5000 mg/kg bw
- Executive summary:
The acute oral LD50 of hexyl salicylate in rats was found to greater than 5000 mg/kg bw, under the conditions of this study. One of 10 rats died; signs of toxicity were imited to urinary incontinence at 24 hours after dosing.
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