Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-690-9 | CAS number: 25167-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The supporting studies by Hydrotox (2004) and Wildlife International (2006) are GLP compliant and follow standard guidelines. They both support the characterisation of 2,4,4 -trimethylpentene as not readily biodegradable. In the EU RAR (2008), it is concluded that, based on the available information a sound assessment of biodegradation is not possible, so as a worst-case 2,4,4-trimethylpentene has to be assessed as not biodegradable. The data are supported by the results from the QSAR estimations using the BIOWINand BioHC models.
One of the screening criteria for persistence in the PBT assessment is that if a substance is considered to be readily biodegradable the substance is screened as not P and not vP. The study conducted by Hydrotox (2004) following OECD test guideline 301B indicated that 2,4,4-trimethylpentene is degraded by 1.6% in 28 days and is therefore not readily biodegradable. Since this substance is not considered to be readily biodegradable it does qualify for a screening assignment of P or vP. The EU RAR (2008) for 2,4,4-trimethylpentene reports a result of 0% biodegradation (BOD) in a MITI-List, Closed Bottle Test (Japan Chemical Industry Ecology-Toxicology & Information Center, 1992). This study was given a reliability of 1 in the EU RAR. On the basis of this information, it is concluded that 2,4,4-trimethylpentene has to be assessed as not biodegradable.
Based on the Biowin predictions, 2,4,4-trimethylpentene meets the screening criteria for P. BioHCwin v1.01 predicts that the half life of 2,4,4-trimethylpentene will be 6.759 days, based on four fragments. These fragments are as follows: a carbon with four single bonds and no hydrogens, a methyl group [-CH3], -CH2- [linear] and a –C=CH [alkenyl hydrogen]. According to a study by Atkinson (1984) the photodegradation half-life for 2,4,4-trimethylpentene was determined to be <1day in the atmosphere and the calculated half-life used in the EU RAR (2008) for 2,4,4-trimethylpentene is 7.24 hours. Due to the weight of evidence, 2,4,4-trimethylpentene is considered to meet the screening criteria for P/vP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.