Registration Dossier
Registration Dossier
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EC number: 247-148-4 | CAS number: 25637-99-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The following information is available for the following investigations.
- Basic Toxicokinetics, metabolism and distribution investigations:
Germer, S., Piersma, A. H., van der Ven, L., Kamyschnikow, A., Fery, Y., Schmitz, H. -J. & Schrenk, D. (2006). Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats. Toxicology (2006) Vol. 218, pp. 229-236.
Scholz, A., Abrahamsson, B., Diebold, S. M., Kostewicz, E., Polentarutti, B. I., Ungell, A. -L., Dressman, J. B. (2002). Influence of Hydrodynamics and Particle Size on the Absorption of Felodipine in Labradors. Pharmaceutical Research (2002), Vol. 19(1).
Canton, R. F., Peijnenburg, A. A. C. M, Hoogenboom, R. L. A. P, Piersma, A. H., van der Ven, L. T. M., van der Berg, M. & Heneweer, M. (2008). Subacute effects of hexabromocyclododecane (HBCD) on hepatic gene expression profiles in rats. Toxicology and Applied Pharmacology (2008), Vol 231, pp. 267-272.
Zeger, B. N., Mets, A., van Bommel, R., Minkenberg, C., Hamers, T., Kamstra, J. H., Learmont, J. A., Vasquez, B. S., Pierce, G., Ried, B., Patterson, T., Rogan, E., Murphy, S., Addink, M., Hartmann, M. G., Smeenk, C., Dabin, W., Ridoux, V., González, A. F., López, A., Jauniaux, T. & Boon, J. P. (2004). Stereo-isomer specific bioaccumulation of hexabromocyclododecane (HBCD) in marine mammals. Third International Workshop on Brominated Flameretardants (BFR) (2004) pp.411-414.
- Dermal absorption:
Roper, C. S. (2005). The in vitro percutaneous absorption of radiolabelled Hexabromocyclododecane (HBCD) through human skin. Testing laboratory: Inveresk, Tranent, EH33 2NE, Scotland, UK. Report no.: 25031. Owner company: American Chemistry Council, Brominated Flame Retardant Industry Panel, Arlington, VA 22209, USA. Report date: 2005-04-26.
Due to the variety and reliability of information available, a weight of evidence approach was used for this endpoint.
Key value for chemical safety assessment
Additional information
A weight of evidence approach was considered to be appropriate to the Toxicokinetic endpoint due to the reliability and variety of information available. Although most of the investigations presented here were conducted on the registered substance, Scholtz et al, 2002, was conducted on a similar substance, and so the standard read-across protocols were used for this investigation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
