Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-599-4 | CAS number: 143-33-9
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The assessment of these studies as from ECETOC 2007 report, Deltombe et al., Gail at al. (published at
Ullmans, 2001) and Ricca et al. showed that a OECD 111 “Hydrolysis depended on pH” study is technically not feasible and
scientifically unjustified.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 6.8 d
- at the temperature of:
- 30 °C
Additional information
The studies of Deltombe, Gail at al., ECETOC 2007 Report and Ricca et al. are reliable study reports and
could be used for a “Weight‐of‐Evidence” approach with validity 2 (study with minor deficits and not
performed according to GLP principles) to describe the performance of hydrolysis of Sodium cyanide
(NaCN) or Potassium cyanide (KCN) under alkaline conditions.
We concluded that according to the used literature the full test of Guideline OECD 111 study should not be
performed on pH 4, 7 and 9 because of the instability of sodium cyanide in water at pH 4 and 7 and
release and high vapor pressure of HCN.
We propose to use the results from literature of Deltombe, Gail and Ricca to describe the performance
of hydrolysis of sodium cyanide (NaCN) under alkaline conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
