Registration Dossier
Registration Dossier
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EC number: 224-073-5 | CAS number: 4193-55-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) Zebra fish > 100 mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
The short term toxicity to fish was tested on the substance but only the test summaries are available. Several studies are reported in a Weight of Evidence approach, with reliability 4. All studies agree in considering the substance as non toxic to fish for acute exposure, with LC50 > 100 mg/l.
A test conducted on the sodium/potassium salt (3a-A(NaK)) analogous was chosen; no signs of toxicity were recorded up to 100 mg/l, after 96 hours of exposure. The analogous substances have the same organic functionalities of the substance under registration, but a different salification: for 3a-A(NaK) the mixture sodium/potassium is used while for the substance only sodium is used. The presence of a complete sodium salification instead than a sodium/potassium mixture of the substance has no impact on general water toxicological properties and the percentage and chemical identity of organic impurities are also very similar. Justification for Read Across is given in Section 13 of IUCLID.
Acute toxicity for Zebra fish was evaluated in the 96 hours screening test, according to the OECD guideline 203. Two doses were administrated at 562 and 1000 mg/l with no effect (Ciba - Geigy Ltd., 1992). The study result is supported by other four studies performed between 1973 and 1999 on Zebra fish at 96h, for which only a summary is available indicating LC50 all greater than 1000 mg/l.
Two fish acute toxicity tests are available (Ciba-Geigy, 1994 and 1998) on 2-A pre-treated with light in order to obtain a high percentage of photodegraded products and verify their impact on aquatic toxicity. Both tests resulted in a LC50 > 100 mg/l, demonstrating that those degradation products are no more dangerous for the environment than the parent compounds.
In conclusion, no fish acute toxicity is expected for the substance
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