Registration Dossier
Registration Dossier
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EC number: 204-818-0 | CAS number: 126-99-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Summary of acute effects of exposure listed in handbook
- GLP compliance:
- no
Test material
- Reference substance name:
- chloroprene
- IUPAC Name:
- chloroprene
- Details on test material:
- - Name of test material (as cited in study report): chloroprene; 2-chlorobutadiene-1,3-; ß-chloroprene
- Molecular formula (if other than submission substance): CH2-CClCH-CH2
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Route of administration:
- other: oral , dermal and inhalation results presented
- Vehicle:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 146 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 mouse
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 450 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 rat
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 3 480 other: mg/m3
- Based on:
- test mat.
- Remarks on result:
- other: LC 50 mouse
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 11 800 other: mg/m3
- Based on:
- test mat.
- Remarks on result:
- other: LC 50 rat
- Other findings:
- intragastric intubation (acute oral) LD50 in mice - 146 mg/kg bw (119-180 fiducial limits)
intragastric intubation (acute oral) LD50 in rat - 450 mg/kg bw (369-550 fiducial limits)
Dermal LD50 in minutes - mouse 78 (57-106); rat 330 (268-406)
Inhalation LC50 mouse 3480 (3000 - 4000) mg/m3 for 2 h exposure; rat 11800 (10500 - 13200) mg/m3 for 4 h exposure
Described as narcotic, affecting internal organs and irritating the upper respiratory tract
Applicant's summary and conclusion
- Conclusions:
- intragastric intubation (acute oral) LD50 in mice - 146 mg/kg bw (119-180 fiducial limits)
intragastric intubation (acute oral) LD50 in rat - 450 mg/kg bw (369-550 fiducial limits)
Dermal LD50 in minutes - mouse 78 (57-106); rat 330 (268-406)
Inhalation LC50 mouse 3480 (3000 - 4000) mg/m3 for 2 h exposure; rat 11800 (10500 - 13200) mg/m3 for 4 h exposure
Described as narcotic, affecting internal organs and irritating the upper respiratory tract
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