Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 265-199-0 | CAS number: 64742-95-6 A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C10 and boiling in the range of approximately 135°C to 210°C (275°F to 410°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report in agreement with OECD guideline 403-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 86290-81-5
- Cas Number:
- 86290-81-5
- IUPAC Name:
- 86290-81-5
- Reference substance name:
- EC-1 regular gasoline
- IUPAC Name:
- EC-1 regular gasoline
- Test material form:
- other: low viscosity liquid hydrocarbon
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sasco, Inc., Omaha, Nebraska
- Age at study initiation: young adults
- Weight at study initiation: approximately 200-300 grams
- Housing: individually
- Diet (e.g. ad libitum): Fresh Certified Rodent feed, ad llibitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 week (7 days)
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68-76 °F
- Humidity (%): 40 to 60 percent relative humidity
- Photoperiod (hrs dark / hrs light): 12hrs dark /12 hrs light
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Rats were exposed in to the test atmosphere in a Hazleton 1000 whole body inhalation chamber. The test atmosphere was generated by delivering the test article to a Sonimist nozzle (nebulizer) under pressure by compressed breathing air
- Volume: 1m3 (1000L)
- Temperature, pressure in air chamber: 23
- Air flow rate: 200 L/min (avg)
TEST ATMOSPHERE
- The test atmosphere shall be generated using an appropriate system selected according to the physical state and characteristics of the test article.
- Groups of individually caged rats will be exposed collectively to the test atmosphere under dynamic air flow conditions for four hours in an appropriate sized whole body chamber (50 in. x 48 in. x 25 in.).
- Air flow rate shall be monitored continuously and documented every thirty minutes
- An exposure environment of at least 19% oxygen shall be insured
-Temperature and humidity shall be monitored continuously and documented every thirty minutes
- Nominal concentrations of test article for each exposure shall be determined gravimetrically
- actual concentrations of airborn test article shall be measured near the breathing zone at one hour intervals during the test period
- particle size distribution measurements shall be made near the breathing zone during the exposed period - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- - nominal (gravimetric) concentration: 7630 +/- 900 mg/m³
- actual (miran) vapor concentration: 5610 +/- 300 mg/m³ - No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- One group of ten rats (5 of each sex) will be collectively exposed to either 5.0 mg/l or the maximum attainable concentration (whichever is the lesser) of the test article. The sponsor representative shall be notified immediately if any deaths occur during the acute screening study. After obtaining the sponsor's representative's approval, groups of twenty rats (10 male, 10 female) will be collectively exposed. Exposure levels for this LC50 study shall be approved by the Sponsor Representative after reviewing the results of the screening study. On post dosing day 13, all surviving animals shall be sacrificed. All animals will undergo a complete gross necropsy.
- Statistics:
- -Mean and standard deviations shall be calculated for animal body weights at the following intervals: day 0, day 7 and termination.
-The ratio of vapor to aerosol phases generated shall be calculated for liquids
-Mean and standard deviations shall be calculated for air flow, temperature, test article concentration and humidity during the testing procedure
-If an LC50 study is performed, median lethal dose values shall be calculated for each sex by an accepted method such as Finney, D.J. (1971) Probit Analysis, 3rd Ed., Cambridge Univ. Press, London. A 95% confidence interval for the median lethal dose should be calculated.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 7 630 mg/m³ air (nominal)
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 610 mg/m³ air (analytical)
- Mortality:
- none
- Clinical signs:
- other: All animals survived to the scheduled sacrifice. There were no remarkable clinical signs noted during the course of treatment.
- Body weight:
- - male rats gained an average of 60 g (s.d. 9 g) with a range of 50-73 g over the two week period
- female rats gained an average of 18 g (s.d. 6 g) with a range of 11-27 g over the two week period - Gross pathology:
- Three of the five male rats exhibited lungs with small round lesions. There were no other visible gross pathological lesions observed on any of the animals at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The inhalation LC50 of test article F-101 is greater than an average nominal (gravimetric) concentration of 7630 +/- 900 mg/m³ and an average actual (calculated by Miran) concentration of 5610 +/- 300 mg/m³. As no mortality effects were noted at the maximum dose tested, these findings do not warrant classification of the test article as an acute inhalation toxicant under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
Five male and five female rats were exposed to an average nominal (gravimetric) concentration of 7630 +/- 900 mg/m³ and an average actual (measured by Miran) vapor concentration of 5610 +/- 300 mg/m³ of test article F-101 for four consecutive hours. No in-life observation effects were observed during the 14 day observation period. At necropsy, three of the five male rats had lung lesions that may be test article related. None of the animals died during the 14 day observation period. Based on the parameters of this study, the inhalation LC50 of test article F-101 is greater than an average nominal (gravimetric) concentration of 7630 +/- 900 mg/m³ and an average actual (calculated by Miran) concentration of 5610 +/- 300 mg/m³. As no mortality effects were noted at the maximum dose tested, these findings do not warrant classification of the test article as an acute inhalation toxicant under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.