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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

There are no long-term test data for invertebrates. Testing is not considered necessary because:

  • Short-term toxicity to aquatic organisms is low.
  • The substance is naturally occurring in aquatic organisms.
  • The substance is readily biodegradable, soluble and unlikely to bioaccumulate.

  

In accordance with Column 2 of REACH Annex IX, the requirement for long-term toxicity data for aquatic invertebrates (required in Section 9.1.5) is waived on the grounds that the chemical safety assessment indicates that it is not necessary.

Key value for chemical safety assessment

Additional information

In accordance with Column 2 of REACH Annex IX, the long-term toxicity data for aquatic invertebrates (required in Section 9.1.5) study does not need to be conducted because the registrant has concluded based on the following safety chemical assessment that long-term toxicity to fish is unlikely to be observed:

- citric acid is essential in the Krebs cycle (or TCA cycle), which is an essential chemical cycle that takes place in all living organisms to generate energy, via the generation of adenosine triphosphate (ATP). This means that citric acid is naturally present inside all living organisms and it is very unlikely that it will be found in the environment at concentrations high enough to exert hazards to organisms;

- the short-term aquatic toxicity data indicate that citric acid is of low toxicity, with EC50 and LC50values >100 mg/L for fish and invertebrates and a NOEC of 425 mg/L for algae. Therefore, long-term effects in studies conducted at standard doses are considered to be unlikely;

- the substance is readily biodegradable, has a log Kow<3 and is highly soluble. Therefore, it is very unlikely to persist in the environment long enough to cause long-term effects and it is not PBT or vPvB.

Overall, it is concluded that the risk characterisation conclusion is sufficiently conservative in respect of any uncertainties and therefore further testing is not considered necessary.